Specific features of collagen implant biodegradation after glaucoma surgery in rabbit eye (experimental study)
Мамиконян В. Р., Фисенко Н. В., Демура Т. А., Коган Е. А., Казарян Е. Е.
Экспериментальная и клиническая фармакология
Т. 81, Вып. 4, С. 22-27
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.30906/0869-2092-2018-81-4-22-27
Аннотация:
The healing process in the adult rabbit conjunctiva and sclera tissues after translimbal microdrainage with the use of either biodegradable antiglaucomatous drainage (BDAD) or iGen was studied. Wound areas showed similar acute inflammatory response to the implantation of both matrixes on the 7th day. Complete lysis degradation of iGen and BDAD was observed on 30th day and 60th day, respectively. Within 60 - 90 days after BDAD implantation, the wound areas of conjunctiva and sclera showed intensive angiogenesis and poor extracellular matrix scarring. In contrast, on the 90th day after iGen implantation, a decrease in angiogenesis and intensive extracellular matrix scar formation were observed. As a result of scarring the thin-walled vessels were compressed, which led to the reduction of aqueous humor outflow. © 2018 Izdatel'stvo Meditsina. All rights reserved.
Ключевые слова:
Angiogenesis; Collagen; Scarring: Aqueous humor outflow: Glaucoma; Wound healing
angiogenesis; Article; biodegradable antiglaucomatous drainage; conjunctiva; extracellular matrix; glaucoma surgery; human; Leporidae; sclera; surgical drainage
Язык текста: Русский
ISSN: 0869-2092
Мамиконян В. Р.
Фисенко Н. В.
Демура Т. А. Татьяна Александровна 1983-
Коган Е. А. Евгения Алтаровна 1951-
Казарян Е. Е.
Mamikonyan V. R.
Fisenko N. V.
Demura T. A. Tat`yana Aleksandrovna 1983-
Kogan E. A. Evgeniya Altarovna 1951-
Kazaryan E. E.
Specific features of collagen implant biodegradation after glaucoma surgery in rabbit eye (experimental study)
Текст визуальный непосредственный
Экспериментальная и клиническая фармакология
ООО "Фолиум"
Т. 81, Вып. 4 С. 22-27
2018
Статья
Angiogenesis Collagen Scarring: Aqueous humor outflow: Glaucoma Wound healing
angiogenesis Article biodegradable antiglaucomatous drainage conjunctiva extracellular matrix glaucoma surgery human Leporidae sclera surgical drainage
The healing process in the adult rabbit conjunctiva and sclera tissues after translimbal microdrainage with the use of either biodegradable antiglaucomatous drainage (BDAD) or iGen was studied. Wound areas showed similar acute inflammatory response to the implantation of both matrixes on the 7th day. Complete lysis degradation of iGen and BDAD was observed on 30th day and 60th day, respectively. Within 60 - 90 days after BDAD implantation, the wound areas of conjunctiva and sclera showed intensive angiogenesis and poor extracellular matrix scarring. In contrast, on the 90th day after iGen implantation, a decrease in angiogenesis and intensive extracellular matrix scar formation were observed. As a result of scarring the thin-walled vessels were compressed, which led to the reduction of aqueous humor outflow. © 2018 Izdatel'stvo Meditsina. All rights reserved.