The effects of gasotransmitters inhibition on biochemical and haematological parameters and oxidative stress in propofol-anaesthetized Wistar male...
Djuric M., Nikolic T. T., Kostic S., Stankovic S., Radonjic K., Djuric D., Zivkovic V., Yakovlevich V., Stevanovic P.
Canadian Journal of Physiology and Pharmacology
Vol.97, Issue11, P. 1073-1079
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1139/cjpp-2019-0029
Аннотация:
This study aimed to investigate the effects of propofol through evaluating its interaction with nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO). Wistar male rats were divided in 4 groups: (1) bolus injection of propofol (1[%] 10 mg/mL, 100 mg/kg bw, i.p.); (2) Nω-nitro-l-arginine methyl ester (L-NAME; NO synthase inhibitor, 60 mg/kg bw, i.p.) + bolus injection of propofol (1[%] 10 mg/mL, 100 mg/kg bw, i.p.); (3) DL-propargylglycine (DL-PAG; H2S synthase inhibitor, 50 mg/kg bw, i.p.) + bolus injection of propofol (1[%] 10 mg/mL, 100 mg/kg bw, i.p.); (4) zinc protoporphyrin IX (ZnPPIX; CO synthase inhibitor, 50 μmol/kg bw, i.p.) + bolus injection of propofol (1[%] 10 mg/mL, 100 mg/kg bw, i.p.). Increased levels of albumins, low-density lipoproteins, alkaline phosphatase, amylase, high-sensitivity Troponin T, and fibrinogen were found in L-NAME + propofol group. Platelet crit, platelet count, total cholesterol, and high-density lipoproteins were elevated in ZnPPIX + propofol g
Ключевые слова:
antioxidative enzymes; biochemical parameters; carbon monoxide; DL-PAG; enzymes antioxydantes; gasotransmitters; gazotransmetteurs; haematological markers; hydrogen sulfide; L-NAME; marqueurs hématologiques; monoxyde de carbone; nitric oxide; oxyde nitrique; paramètres biochimiques; propofol; sulfure d’hydrogène; ZnPPIX
anesthetic agent; biological marker; gasotransmitter; homocysteine; propofol; animal; blood; blood examination; drug effect; hemostasis; male; oxidative stress; rat; Wistar rat; Anesthetics; Animals; Biomarkers; Gasotransmitters; Hematologic Tests; Hemostasis; Homocysteine; Male; Oxidative Stress; Propofol; Rats; Rats, Wistar
Язык текста: Английский
ISSN: 1205-7541
Djuric M.
Nikolic T. T. Turnic T.
Kostic S.
Stankovic S.
Radonjic K.
Djuric D.
Zivkovic V.
Yakovlevich V. Vladimir 1971-
Stevanovic P.
Дйуриc М.
Николиc Т. Т. Тюрниc Т.
Костиc С.
Станковиc С.
Радонйиc К.
Дйуриc Д.
Зивковиc В.
Яковлевич В. Владимир 1971-
Стевановиc П.
The effects of gasotransmitters inhibition on biochemical and haematological parameters and oxidative stress in propofol-anaesthetized Wistar male rats
The effects of gasotransmitters inhibition on biochemical and haematological parameters and oxidative stress in propofol-anaesthetized Wistar male...
Текст визуальный непосредственный
Canadian Journal of Physiology and Pharmacology
NRC Research Press
Vol.97, Issue11 P. 1073-1079
2019
Статья
antioxidative enzymes biochemical parameters carbon monoxide DL-PAG enzymes antioxydantes gasotransmitters gazotransmetteurs haematological markers hydrogen sulfide L-NAME marqueurs hématologiques monoxyde de carbone nitric oxide oxyde nitrique paramètres biochimiques propofol sulfure d’hydrogène ZnPPIX
anesthetic agent biological marker gasotransmitter homocysteine propofol animal blood blood examination drug effect hemostasis male oxidative stress rat Wistar rat Anesthetics Animals Biomarkers Gasotransmitters Hematologic Tests Hemostasis Homocysteine Male Oxidative Stress Propofol Rats Rats, Wistar
This study aimed to investigate the effects of propofol through evaluating its interaction with nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO). Wistar male rats were divided in 4 groups: (1) bolus injection of propofol (1[%] 10 mg/mL, 100 mg/kg bw, i.p.); (2) Nω-nitro-l-arginine methyl ester (L-NAME; NO synthase inhibitor, 60 mg/kg bw, i.p.) + bolus injection of propofol (1[%] 10 mg/mL, 100 mg/kg bw, i.p.); (3) DL-propargylglycine (DL-PAG; H2S synthase inhibitor, 50 mg/kg bw, i.p.) + bolus injection of propofol (1[%] 10 mg/mL, 100 mg/kg bw, i.p.); (4) zinc protoporphyrin IX (ZnPPIX; CO synthase inhibitor, 50 μmol/kg bw, i.p.) + bolus injection of propofol (1[%] 10 mg/mL, 100 mg/kg bw, i.p.). Increased levels of albumins, low-density lipoproteins, alkaline phosphatase, amylase, high-sensitivity Troponin T, and fibrinogen were found in L-NAME + propofol group. Platelet crit, platelet count, total cholesterol, and high-density lipoproteins were elevated in ZnPPIX + propofol g