Biological activity of liposomal silibinin
Фельдман Н. Б., Гудкова О. И., Куряков В. Н., Громовых Т. И., Баранова А. А., Садyкова В. С., Луценко С. В.
Антибиотики и химиотерапия
Т. 62, Вып. 9-10, С. 9-14
Опубликовано: 2017
Тип ресурса: Статья
Аннотация:
The aim of the study was to obtain and characterize liposomal silibinin, as well as to study its antitumor and antimicrobial activity. Liposomes were obtained by hydration of a thin-layer film with a buffer solution followed by multiple freezing-thawing of the dispersion of phosphatidylcholine-cholesterol-silibinin. It has been established that liposomal silibinin has an inhibitory effect against liver (HepG2 line) and prostate gland (DU145 line) tumor cells. In addition, liposomalosilinin has a pronounced antibacterial effect against bacteria and a fungistatic effect on toxigenic micromycetes, which may indicate its effectiveness as an antimicrobial and fungistatic agent for reducing the negative effect of mycotoxins of mold fungi. © 2017 Media Sphera Publishing Group. All rights reserved.
Ключевые слова:
Antimicrobial activity; Antitumor activity; Liposomes; Silibinin
Язык текста: Русский
ISSN: 0235-2990
Фельдман Н. Б. Наталия Борисовна 1969-
Гудкова О. И. Оксана Игоревна 1995-
Куряков В. Н.
Громовых Т. И. Татьяна Ильинична 1950-
Баранова А. А.
Садyкова В. С.
Луценко С. В. Сергей Викторович 1957-
Fel`dman N. B. Nataliya Borisovna 1969-
Gudkova O. I. Oksana Igorevna 1995-
Kuryakov V. N.
Gromovy'kh T. I. Tat`yana Il`inichna 1950-
Baranova A. A.
Sadykova V. S.
Lutsenko S. V. Sergej Viktorovich 1957-
Biological activity of liposomal silibinin
Текст визуальный непосредственный
Антибиотики и химиотерапия
Издательство ОКИ
Т. 62, Вып. 9-10 С. 9-14
2017
Статья
Antimicrobial activity Antitumor activity Liposomes Silibinin
The aim of the study was to obtain and characterize liposomal silibinin, as well as to study its antitumor and antimicrobial activity. Liposomes were obtained by hydration of a thin-layer film with a buffer solution followed by multiple freezing-thawing of the dispersion of phosphatidylcholine-cholesterol-silibinin. It has been established that liposomal silibinin has an inhibitory effect against liver (HepG2 line) and prostate gland (DU145 line) tumor cells. In addition, liposomalosilinin has a pronounced antibacterial effect against bacteria and a fungistatic effect on toxigenic micromycetes, which may indicate its effectiveness as an antimicrobial and fungistatic agent for reducing the negative effect of mycotoxins of mold fungi. © 2017 Media Sphera Publishing Group. All rights reserved.