Antimicrobial activity of branched oligo(hexamethyleneguanidine) hydrochloride on oral pathogens
Shatalov D. O., Kedik S. A., Panov A. V., Zhavoronok E. S., Aydakova A. V., Kovalenko A. V., Morozova O. A., Makeeva I. M., Dezhurko-Korol` V. A.
Russian Open Medical Journal
Vol.7, Issue3, Num.e0309
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.15275/rusomj.2018.0309
Аннотация:
The present work is devoted to study of the antimicrobial activity of a new promising synthetic biocidal compound, branched oligohexamethylene guanidine hydrochloride. The studies were carried out using optional anaerobic bacteria Staphylococcus aureus and Klebsiella pneumoniae, as well as obligate anaerobic bacteria Actinomyces pyogenes, Actinomyces odontolyticus, Peptostreptococcus micros, Finegoldia magna, Veillonella parvula, Prevotella disiens and Fusobacterium nucleatum. It was shown that branched oligohexamethylene guanidine hydrochloride inhibits the growth of these bacteria, and facultative anaerobic bacteria are more sensitive to it. The assumptions about the mechanism of this activity of branched oligohexamethylene guanidine hydrochloride are made. The results of the study show that the substance can be recommended as a broad-spectrum biocide. © 2017, Shatalov D.O., Kedik S.A., Panov A.V., Zhavoronok E.S., Aydakova A.V., Kovalenko A.V., Morozova O.A., Makeeva I.M., Dezhurko-
Ключевые слова:
Antimicrobial activity; Branched oligo(hexamethyleneguanidine) hydrochloride; Oral pathogens
guanidine; oligohexamethylene guanidine hydrochloride; unclassified drug; Actinomyces; Actinomyces odontolyticus; antimicrobial activity; Article; bacterial membrane; bactericidal activity; Finegoldia magna; Fusobacterium nucleatum; Klebsiella pneumoniae; minimum inhibitory concentration; nonhuman; Parvimonas micra; Prevotella disiens; Staphylococcus aureus; Trueperella pyogenes; Veillonella parvula
Язык текста: Английский
ISSN: 2304-3415
Shatalov D. O.
Kedik S. A.
Panov A. V.
Zhavoronok E. S.
Aydakova A. V.
Kovalenko A. V.
Morozova O. A. Ol`ga Alekseevna 1958-
Makeeva I. M. Irina Mikhaylovna 1963-
Dezhurko-Korol` V. A. Viktoriya Andreevna 1991-
Шаталов Д. О.
Кедик С. А.
Панов А. В.
Жаворонок Е. С.
Айдакова А. В.
Коваленко А. В.
Морозова О. А. Ольга Алексеевна 1958-
Макеева И. М. Ирина Михайловна 1963-
Дежурко-Король В. А. Виктория Андреевна 1991-
Antimicrobial activity of branched oligo(hexamethyleneguanidine) hydrochloride on oral pathogens
Текст визуальный непосредственный
Russian Open Medical Journal
Наука и инновации
Vol.7, Issue3 Num.e0309
2018
Статья
Antimicrobial activity Branched oligo(hexamethyleneguanidine) hydrochloride Oral pathogens
guanidine oligohexamethylene guanidine hydrochloride unclassified drug Actinomyces Actinomyces odontolyticus antimicrobial activity Article bacterial membrane bactericidal activity Finegoldia magna Fusobacterium nucleatum Klebsiella pneumoniae minimum inhibitory concentration nonhuman Parvimonas micra Prevotella disiens Staphylococcus aureus Trueperella pyogenes Veillonella parvula
The present work is devoted to study of the antimicrobial activity of a new promising synthetic biocidal compound, branched oligohexamethylene guanidine hydrochloride. The studies were carried out using optional anaerobic bacteria Staphylococcus aureus and Klebsiella pneumoniae, as well as obligate anaerobic bacteria Actinomyces pyogenes, Actinomyces odontolyticus, Peptostreptococcus micros, Finegoldia magna, Veillonella parvula, Prevotella disiens and Fusobacterium nucleatum. It was shown that branched oligohexamethylene guanidine hydrochloride inhibits the growth of these bacteria, and facultative anaerobic bacteria are more sensitive to it. The assumptions about the mechanism of this activity of branched oligohexamethylene guanidine hydrochloride are made. The results of the study show that the substance can be recommended as a broad-spectrum biocide. © 2017, Shatalov D.O., Kedik S.A., Panov A.V., Zhavoronok E.S., Aydakova A.V., Kovalenko A.V., Morozova O.A., Makeeva I.M., Dezhurko-