Ventilator-induced diaphragm dysfunction
Babaev M. A., Бyков Д. Б., Birg T. M., Vyzhigina M. A., Eremenko A. A.
Общая реаниматология
Т. 14, Вып. 3, С. 82-103
Опубликовано: 2018
Тип ресурса: Обзор
DOI:10.15360/1813-9779-2018-3-82-103
Аннотация:
Mechanical ventilation is associated with a number of complications that increase the cost of treatment and the hospital mortality rate. In 2004, the term «ventilator-induced diaphragm dysfunction» (VIDD) was proposed to explain one of the reasons for the failure of respiratory support. At present, this term is understood as a combination of atrophy and weakness of the contractile function of the diaphragm caused directly by a long-term mechanical lung ventilation. Oxidative stress, proteolysis, mitochondrial dysfunction, as well as passive overdistension of the diaphragm fibers contribute greatly to the pathogenesis of VIDD. Since 30—80[%] of patients in the ICU require mechanical respiratory support and even 6—8 hours of mechanical lung ventilation can contribute to the development of a significant weakness of the diaphragm, it can be concluded that the VIDD is an extremely urgent problem in most patients. Its typical clinical presentation is characterized by impaired breathing mechani
Ключевые слова:
Mechanical ventilation; Mitochondrial dysfunction; Oxidative stress; Ventilation modes; Ventilator-induced diaphragm dysfunction
Язык текста: Русский
ISSN: 2411-7110
Babaev M. A.
Бyков Д. Б.
Birg T. M. Tat`yana Mikhaylovna 1993-
Vyzhigina M. A.
Eremenko A. A.
Бабаев М. А.
Bykov D. B.
Бирг Т. М. Татьяна Михайловна 1993-
Вyжигина М. А.
Еременко А. А.
Ventilator-induced diaphragm dysfunction
Текст визуальный непосредственный
Общая реаниматология
Некоммерческая организация Фонд "Медицина критических состояний"
Т. 14, Вып. 3 С. 82-103
2018
Обзор
Mechanical ventilation Mitochondrial dysfunction Oxidative stress Ventilation modes Ventilator-induced diaphragm dysfunction
Mechanical ventilation is associated with a number of complications that increase the cost of treatment and the hospital mortality rate. In 2004, the term «ventilator-induced diaphragm dysfunction» (VIDD) was proposed to explain one of the reasons for the failure of respiratory support. At present, this term is understood as a combination of atrophy and weakness of the contractile function of the diaphragm caused directly by a long-term mechanical lung ventilation. Oxidative stress, proteolysis, mitochondrial dysfunction, as well as passive overdistension of the diaphragm fibers contribute greatly to the pathogenesis of VIDD. Since 30—80[%] of patients in the ICU require mechanical respiratory support and even 6—8 hours of mechanical lung ventilation can contribute to the development of a significant weakness of the diaphragm, it can be concluded that the VIDD is an extremely urgent problem in most patients. Its typical clinical presentation is characterized by impaired breathing mechani