EPR Characterization of Dinitrosyl Iron Complexes with Thiol-Containing Ligands as an Approach to Their Identification in Biological Objects: An...
Vanin A. F.
Cell Biochemistry and Biophysics
Vol.76, Issue1-2, P. 3-17
Опубликовано: 2018
Тип ресурса: Обзор
DOI:10.1007/s12013-017-0811-8
Аннотация:
The overview demonstrates how the use of only one physico-chemical approach, viz., the electron paramagnetic resonance method, allowed detection and identification of dinitrosyl iron complexes with thiol-containing ligands in various animal and bacterial cells. These complexes are formed in biological objects in the paramagnetic (electron paramagnetic resonance-active) mononuclear and diamagnetic (electron paramagnetic resonance-silent) binuclear forms and control the activity of nitrogen monoxide, one of the most universal regulators of metabolic processes in the organism. The analysis of electronic and spatial structures of dinitrosyl iron complex sheds additional light on the mechanism whereby dinitrosyl iron complex with thiol-containing ligands function in human and animal cells as donors of nitrogen monoxide and its ionized form, viz., nitrosonium ions (NO+). © 2017, Springer Science+Business Media, LLC.
Ключевые слова:
Dinitrosyl iron complexes; EPR spectroscopy; Living objects; Nitrogen monoxide; Thiol-containing ligands
dinitrosyl iron complex; glutathione; iron; ligand; nitric oxide; nitrogen oxide; thiol derivative; animal; chemistry; electron spin resonance; human; liver; metabolism; Saccharomyces cerevisiae; Animals; Electron Spin Resonance Spectroscopy; Glutathione; Humans; Iron; Ligands; Liver; Nitric Oxide; Nitrogen Oxides; Saccharomyces cerevisiae; Sulfhydryl Compounds
Язык текста: Английский
ISSN: 1559-0283
Vanin A. F.
Ванин А. Ф.
EPR Characterization of Dinitrosyl Iron Complexes with Thiol-Containing Ligands as an Approach to Their Identification in Biological Objects: An Overview
EPR Characterization of Dinitrosyl Iron Complexes with Thiol-Containing Ligands as an Approach to Their Identification in Biological Objects: An...
Текст визуальный непосредственный
Cell Biochemistry and Biophysics
Humana Press, Inc.
Vol.76, Issue1-2 P. 3-17
2018
Обзор
Dinitrosyl iron complexes EPR spectroscopy Living objects Nitrogen monoxide Thiol-containing ligands
dinitrosyl iron complex glutathione iron ligand nitric oxide nitrogen oxide thiol derivative animal chemistry electron spin resonance human liver metabolism Saccharomyces cerevisiae Animals Electron Spin Resonance Spectroscopy Glutathione Humans Iron Ligands Liver Nitric Oxide Nitrogen Oxides Saccharomyces cerevisiae Sulfhydryl Compounds
The overview demonstrates how the use of only one physico-chemical approach, viz., the electron paramagnetic resonance method, allowed detection and identification of dinitrosyl iron complexes with thiol-containing ligands in various animal and bacterial cells. These complexes are formed in biological objects in the paramagnetic (electron paramagnetic resonance-active) mononuclear and diamagnetic (electron paramagnetic resonance-silent) binuclear forms and control the activity of nitrogen monoxide, one of the most universal regulators of metabolic processes in the organism. The analysis of electronic and spatial structures of dinitrosyl iron complex sheds additional light on the mechanism whereby dinitrosyl iron complex with thiol-containing ligands function in human and animal cells as donors of nitrogen monoxide and its ionized form, viz., nitrosonium ions (NO+). © 2017, Springer Science+Business Media, LLC.