Predictors of hepatic insufficiency in obstructive jaundice [Prediktory pechenochnoĭ nedostatochnosti pri mekhanicheskoĭ zheltukhe]
Винник Y. С., Пахомова Р. А., Кочетова Л. В., Воронова Е. А., Козлов В. В., Кириченко А. К.
Хирургия. Журнал им. Н.И. Пирогова
Вып. 3, С. 37-41
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.17116/hirurgia2018337-41
Аннотация:
AIM: To develop predictive model for hepatic insufficiency in obstructive jaundice.MATERIAL AND METHODS: Obstructive jaundice was modeled by the author's method on 48 mini pigs, while morpho-functional features of erythrocytes were studied by using of INTEGRA Aura atomic force microscope (NT-MDT, Zelenograd, Russia). Histological specimens were stained with hematoxylin and eosin. Discriminant analysis was used to create predictive model for hepatic insufficiency.RESULTS: Mathematical model of hepatic insufficiency prediction has been developed. Sensitivity and specificity of this model were 94.1[%] and 74.2[%] respectively. Total percentage of correct predictions was 81.3[%].CONCLUSION: Severe obstructive jaundice contributes erythrocyte's transformation from biconcave to dome-shaped followed by changes of its physical properties. Erythrocyte's volume and activity of cytolysis enzymes are the most informative to predict hepatic insufficiency. Our model allows us to diagnose this complication
Ключевые слова:
atomic force microscopy; discriminant analysis; erythrocyte’s membrane; hepatic insufficiency; liver histology; obstructive jaundice
abdominal surgery; animal; atomic force microscopy; blood; complication; enzymology; liver; liver failure; liver function test; mean corpuscular volume; minipig; obstructive jaundice; pathology; peroperative complication; pig; postoperative complication; predictive value; procedures; prognosis; severity of illness index; Animals; Digestive System Surgical Procedures; Erythrocyte Indices; Hepatic Insufficiency; Intraoperative Complications; Jaundice, Obstructive; Liver; Liver Function Tests; Microscopy, Atomic Force; Postoperative Complications; Predictive Value of Tests; Prognosis; Severity of Illness Index; Swine; Swine, Miniature
Язык текста: Русский
ISSN: 2309-5628
Винник Y. С.
Пахомова Р. А.
Кочетова Л. В.
Воронова Е. А.
Козлов В. В. Василий Владимирович 1974-
Кириченко А. К.
Vinnik Y. S.
Pakhomova R. A.
Kochetova L. V.
Voronova E. A.
Kozlov V. V. Vasilij Vladimirovich 1974-
Kirichenko A. K.
Predictors of hepatic insufficiency in obstructive jaundice [Prediktory pechenochnoĭ nedostatochnosti pri mekhanicheskoĭ zheltukhe]
Текст визуальный непосредственный
Хирургия. Журнал им. Н.И. Пирогова
Издательство Медиа Сфера
Вып. 3 С. 37-41
2018
Статья
atomic force microscopy discriminant analysis erythrocyte’s membrane hepatic insufficiency liver histology obstructive jaundice
abdominal surgery animal atomic force microscopy blood complication enzymology liver liver failure liver function test mean corpuscular volume minipig obstructive jaundice pathology peroperative complication pig postoperative complication predictive value procedures prognosis severity of illness index Animals Digestive System Surgical Procedures Erythrocyte Indices Hepatic Insufficiency Intraoperative Complications Jaundice, Obstructive Liver Liver Function Tests Microscopy, Atomic Force Postoperative Complications Predictive Value of Tests Prognosis Severity of Illness Index Swine Swine, Miniature
AIM: To develop predictive model for hepatic insufficiency in obstructive jaundice.MATERIAL AND METHODS: Obstructive jaundice was modeled by the author's method on 48 mini pigs, while morpho-functional features of erythrocytes were studied by using of INTEGRA Aura atomic force microscope (NT-MDT, Zelenograd, Russia). Histological specimens were stained with hematoxylin and eosin. Discriminant analysis was used to create predictive model for hepatic insufficiency.RESULTS: Mathematical model of hepatic insufficiency prediction has been developed. Sensitivity and specificity of this model were 94.1[%] and 74.2[%] respectively. Total percentage of correct predictions was 81.3[%].CONCLUSION: Severe obstructive jaundice contributes erythrocyte's transformation from biconcave to dome-shaped followed by changes of its physical properties. Erythrocyte's volume and activity of cytolysis enzymes are the most informative to predict hepatic insufficiency. Our model allows us to diagnose this complication