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Clinical and economic aspects of using a novel Russian non-nucleoside reverse transcriptase inhibitor elsulfavirine as a first-line treatment of...

Ряженов В. В., Горохова С. Г.
Инфекционные болезни
Т. 16, Вып. 2, С. 11-17
Опубликовано: 2018
Тип ресурса: Статья

DOI:10.20953/1729-9225-2018-2-11-17

Аннотация:
The objective. To perform a budget impact analysis of a novel antiretroviral drug elsulfavirine (ESV) compared with currently used medical technologies. Materials and methods. The pharmacoeconomic model was based on the studies of efficacy and safety of two non-nucleoside reverse transcriptase inhibitors: ESV and rilpivirine (RPV) combined with standard basic tenofovir/ emtricitabine (TDF/FTC) therapy for 48 weeks. The studies were performed in similar clinical settings. The budget impact analysis assessed only direct medical costs of antiretroviral drugs within the chosen strategies of first-line antiretroviral therapy (ART). Results. It was shown that the treatment of ART-naive HIV patients with ESV is associated with 61,234.88 RUB less costs per patient in a 48-week course compared with RPV treatment. The analyzed values of cost effectiveness were lower for ESV strategy than for the strategy with the use of RPV. It makes ESV a more cost-efficient option within the developed model. C
Ключевые слова:
Antiretroviral therapy; Elsulfavirine; HIV
Язык текста: Русский
ISSN: 2414-9691
Ряженов В. В. Василий Вячеславович 1976-
Горохова С. Г. Светлана Георгиевна 1959-
Ryazhenov V. V. Vasilij Vyacheslavovich 1976-
Gorokhova S. G. Svetlana Georgievna 1959-
Clinical and economic aspects of using a novel Russian non-nucleoside reverse transcriptase inhibitor elsulfavirine as a first-line treatment of HIV infection in patients starting antiretroviral therapy for the first time
Clinical and economic aspects of using a novel Russian non-nucleoside reverse transcriptase inhibitor elsulfavirine as a first-line treatment of...
Текст визуальный непосредственный
Инфекционные болезни
ООО "Издательство "Династия"
Т. 16, Вып. 2 С. 11-17
2018
Статья
Antiretroviral therapy Elsulfavirine HIV
The objective. To perform a budget impact analysis of a novel antiretroviral drug elsulfavirine (ESV) compared with currently used medical technologies. Materials and methods. The pharmacoeconomic model was based on the studies of efficacy and safety of two non-nucleoside reverse transcriptase inhibitors: ESV and rilpivirine (RPV) combined with standard basic tenofovir/ emtricitabine (TDF/FTC) therapy for 48 weeks. The studies were performed in similar clinical settings. The budget impact analysis assessed only direct medical costs of antiretroviral drugs within the chosen strategies of first-line antiretroviral therapy (ART). Results. It was shown that the treatment of ART-naive HIV patients with ESV is associated with 61,234.88 RUB less costs per patient in a 48-week course compared with RPV treatment. The analyzed values of cost effectiveness were lower for ESV strategy than for the strategy with the use of RPV. It makes ESV a more cost-efficient option within the developed model. C