Influence of aging-induced flow waveform variation on hemodynamics in aneurysms present at the internal carotid artery: A computational model-based...
Xu L., Lyan F., Zhao B., Wan J., Liu H.
Computers in Biology and Medicine
Vol.101, P. 51-60
Опубликовано: 2018
Тип ресурса: Статья
DOI:10.1016/j.compbiomed.2018.08.004
Аннотация:
The variation of blood flow waveform in the internal carotid artery (ICA) with age is a well-documented hemodynamic phenomenon, but little is known about how such variation affects the characteristics of blood flow in aneurysms present in the region. In the study, hemodynamic simulations were conducted for 26 ICA aneurysms, with flow waveforms measured in the ICAs of young and older adults being used respectively to set the inflow boundary conditions. Obtained results showed that replacing the young-adult flow waveform with the older-adult one led to little changes (<10[%]) in simulated time-averaged wall shear stress (WSS), transient maximum WSS, relative residence time and trans-aneurysm pressure loss coefficient, but resulted in a marked increase (32.36 ± 17.24[%]) in oscillatory shear index (OSI). Frequency-domain wave analysis revealed that the progressive enhancement of low-frequency harmonics dominated the observed flow waveform variation with age and was a major factor contributing
Ключевые слова:
Aging; Aneurysm; Flow waveform; Hemodynamics; Internal carotid artery
Aging of materials; Aspect ratio; Blood; Blood vessels; Boundary conditions; Frequency domain analysis; Oscillating flow; Shear flow; Shear stress; Aneurysm; Flow waveforms; Inflow boundary conditions; Internal carotid artery; Morphological features; Oscillatory shear index; Pressure loss coefficient; Progressive enhancement; Hemodynamics; age; aging; Article; computational fluid dynamics; hemodynamics; internal carotid artery aneurysm; morphology; priority journal; shear stress; simulation; waveform; adult; aged; biological model; carotid artery disease; female; human; internal carotid artery; intracranial aneurysm; male; mechanical stress; middle aged; pathology; pathophysiology; Adult; Aged; Carotid Artery Diseases; Carotid Artery, Internal; Female; Hemodynamics; Humans; Intracranial Aneurysm; Male; Middle Aged; Models, Cardiovascular; Stress, Mechanical
Язык текста: Английский
ISSN: 1879-0534
Xu L.
Lyan F. Fuyu 1978-
Zhao B.
Wan J.
Liu H.
Ху Л.
Лян Ф. Фую 1978-
Жао Б.
Wан Й.
Лиу Х.
Influence of aging-induced flow waveform variation on hemodynamics in aneurysms present at the internal carotid artery: A computational model-based study
Influence of aging-induced flow waveform variation on hemodynamics in aneurysms present at the internal carotid artery: A computational model-based...
Текст визуальный непосредственный
Computers in Biology and Medicine
Elsevier Science Publisher B.V.
Vol.101 P. 51-60
2018
Статья
Aging Aneurysm Flow waveform Hemodynamics Internal carotid artery
Aging of materials Aspect ratio Blood Blood vessels Boundary conditions Frequency domain analysis Oscillating flow Shear flow Shear stress Aneurysm Flow waveforms Inflow boundary conditions Internal carotid artery Morphological features Oscillatory shear index Pressure loss coefficient Progressive enhancement Hemodynamics age aging Article computational fluid dynamics hemodynamics internal carotid artery aneurysm morphology priority journal shear stress simulation waveform adult aged biological model carotid artery disease female human internal carotid artery intracranial aneurysm male mechanical stress middle aged pathology pathophysiology Adult Aged Carotid Artery Diseases Carotid Artery, Internal Female Hemodynamics Humans Intracranial Aneurysm Male Middle Aged Models, Cardiovascular Stress, Mechanical
The variation of blood flow waveform in the internal carotid artery (ICA) with age is a well-documented hemodynamic phenomenon, but little is known about how such variation affects the characteristics of blood flow in aneurysms present in the region. In the study, hemodynamic simulations were conducted for 26 ICA aneurysms, with flow waveforms measured in the ICAs of young and older adults being used respectively to set the inflow boundary conditions. Obtained results showed that replacing the young-adult flow waveform with the older-adult one led to little changes (<10[%]) in simulated time-averaged wall shear stress (WSS), transient maximum WSS, relative residence time and trans-aneurysm pressure loss coefficient, but resulted in a marked increase (32.36 ± 17.24[%]) in oscillatory shear index (OSI). Frequency-domain wave analysis revealed that the progressive enhancement of low-frequency harmonics dominated the observed flow waveform variation with age and was a major factor contributing