Key elements of toxic myocardiopathy pathogenesis [Ключевые звенья патогенеза токсической миокардиопатии]
Бунятян Н. Д., Власова Т. И., Мyшкина Н. А., Власов А. П., Полозова Е. И., Лешчанкина Н. Y., Прокофьев А. Б., Гуревич К. Г.
Бюллетень сибирской медицины
Т. 18, Вып. 2, С. 24-30
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.20538/1682-0363-2019-2-24-30
Аннотация:
Goal. To identify key links in the pathogenesis of toxic myocardiopathy in conditions of endogenous intoxication in peritonitis. Materials and methods. Experimental studies were carried out on dogs (n = 24). The model of purulent fecal peritonitis. We studied the run-time content of toxic products in blood plasma, the lipid composition, the intensity of lipid peroxidation, the activity of phospholipase A2 and superoxide dismutase, and hypoxia of myocardial tissue. We evaluated loss of water and proteins, electrogenesis of the myocardium cells and changes in the ECG parameters. We also performed histological examination of the myocardial tissue. Results. Experimental studies in dogs showed that the development of endotoxicosis of peritoneal origin is accompanied by significant metabolic disorders and cardiac malfunction leading to the development of myocardiopathy. The most important role in the development and progression of myocardial damage in endotoxicosis is played by biomembrane d
Ключевые слова:
Endogenous intoxication; Myocardiopathy; Peritonitis
Язык текста: Русский
ISSN: 1819-3684
Бунятян Н. Д. Наталья Дмитриевна 1955-
Власова Т. И.
Мyшкина Н. А.
Власов А. П.
Полозова Е. И.
Лешчанкина Н. Y. Н.Ю.
Прокофьев А. Б. Алексей Борисович 1964-
Гуревич К. Г.
Bunyatyan N. D. Natal`ya Dmitrievna 1955-
Vlasova T. I.
Myshkina N. A.
Vlasov A. P.
Polozova E. I.
Leshchankina N. Y. N.Yu.
Prokofyev A. B. Aleksej Borisovich 1964-
Gurevich K. G.
Key elements of toxic myocardiopathy pathogenesis [Ключевые звенья патогенеза токсической миокардиопатии]
Текст визуальный непосредственный
Бюллетень сибирской медицины
Сибирский государственный медицинский университет
Т. 18, Вып. 2 С. 24-30
2019
Статья
Endogenous intoxication Myocardiopathy Peritonitis
Goal. To identify key links in the pathogenesis of toxic myocardiopathy in conditions of endogenous intoxication in peritonitis. Materials and methods. Experimental studies were carried out on dogs (n = 24). The model of purulent fecal peritonitis. We studied the run-time content of toxic products in blood plasma, the lipid composition, the intensity of lipid peroxidation, the activity of phospholipase A2 and superoxide dismutase, and hypoxia of myocardial tissue. We evaluated loss of water and proteins, electrogenesis of the myocardium cells and changes in the ECG parameters. We also performed histological examination of the myocardial tissue. Results. Experimental studies in dogs showed that the development of endotoxicosis of peritoneal origin is accompanied by significant metabolic disorders and cardiac malfunction leading to the development of myocardiopathy. The most important role in the development and progression of myocardial damage in endotoxicosis is played by biomembrane d