Zinc, copper, and oxysterol levels in patients with type 1 and type 2 diabetes mellitus
Samadi A., Isikhan S. Y., Tin`kov A. A., Lay I., Doşa M. D., Skal`ny'j A. V., Skal`naya M. G., Chirumbolo S., Bjørklund G.
Clinical Nutrition
Vol.39, Issue6, P. 1849-1856
Опубликовано: 2020
Тип ресурса: Статья
DOI:10.1016/j.clnu.2019.07.026
Аннотация:
Background: The present study has the objective to assess the zinc (Zn), copper (Cu), and oxysterols plasma levels in type 1 (DM1) (n = 26) and type 2 (DM2) (n = 80) diabetes patients, as compared to healthy controls (n = 71), in order to testify whether metal levels may have a significant impact on the association between oxysterols and diabetes. Methods: Plasma trace elements and plasma oxysterols were assessed using atomic absorption spectrometry and LC-MS/MS, respectively. Lifestyle, smoking status, alcohol intake, and drug usage, as well as microvascular complications, were also monitored and reported. Results: The obtained data demonstrated that both DM1 and DM2 patients were characterized by significantly elevated HbA1c, FBG, TC, LDL-C, VLDL-C, and TG levels as compared to controls. Plasma Zn levels and Zn/Cu ratio in DM1 and DM2 patients were about 3- and 2-fold lower than controls. No significant differences in plasma Cu levels were reported. The 7-ketocholesterol (7-kchol) le
Ключевые слова:
Copper; Diabetes mellitus; Oxysterol; Zinc
7 oxocholesterol; acetylsalicylic acid; antidiabetic agent; antihypertensive agent; antioxidant; captopril; cholesterol derivative; copper; enalapril; glucose; hemoglobin A1c; hydroxymethylglutaryl coenzyme A reductase inhibitor; insulin; kaptoril; low density lipoprotein cholesterol; metformin; oral antidiabetic agent; oxysterol; ramipril; triacylglycerol; very low density lipoprotein cholesterol; zinc; adult; alcohol consumption; anthropometric parameters; Article; atomic absorption spectrometry; biochemical composition; cholesterol blood level; controlled study; copper blood level; diabetic patient; drug use; fasting; female; glucose blood level; human; hypertension; insulin dependent diabetes mellitus; lifestyle; lipid blood level; liquid chromatography-mass spectrometry; major clinical study; male; metabolic parameters; microangiopathy; middle aged; non insulin dependent diabetes mellitus; oxysterol blood level; patient monitoring; people by smoking status; zinc blood level
Язык текста: Английский
ISSN: 1532-1983
Samadi A.
Isikhan S. Y.
Tin`kov A. A. Aleksej Alekseevich 1989-
Lay I.
Doşa M. D.
Skal`ny'j A. V. Anatolij Viktorovich 1962-
Skal`naya M. G. Margarita Gennadievna 1968-
Chirumbolo S.
Bjørklund G.
Самади А.
Исихан С. Y.
Тиньков А. А. Алексей Алексеевич 1989-
Лай И.
Доşа М. Д.
Скальный А. В. Анатолий Викторович 1962-
Скальная М. Г. Маргарита Геннадиевна 1968-
Чирумболо С.
Бйøрклунд Г.
Zinc, copper, and oxysterol levels in patients with type 1 and type 2 diabetes mellitus
Текст визуальный непосредственный
Clinical Nutrition
Churchill Livingstone
Vol.39, Issue6 P. 1849-1856
2020
Статья
Copper Diabetes mellitus Oxysterol Zinc
7 oxocholesterol acetylsalicylic acid antidiabetic agent antihypertensive agent antioxidant captopril cholesterol derivative copper enalapril glucose hemoglobin A1c hydroxymethylglutaryl coenzyme A reductase inhibitor insulin kaptoril low density lipoprotein cholesterol metformin oral antidiabetic agent oxysterol ramipril triacylglycerol very low density lipoprotein cholesterol zinc adult alcohol consumption anthropometric parameters Article atomic absorption spectrometry biochemical composition cholesterol blood level controlled study copper blood level diabetic patient drug use fasting female glucose blood level human hypertension insulin dependent diabetes mellitus lifestyle lipid blood level liquid chromatography-mass spectrometry major clinical study male metabolic parameters microangiopathy middle aged non insulin dependent diabetes mellitus oxysterol blood level patient monitoring people by smoking status zinc blood level
Background: The present study has the objective to assess the zinc (Zn), copper (Cu), and oxysterols plasma levels in type 1 (DM1) (n = 26) and type 2 (DM2) (n = 80) diabetes patients, as compared to healthy controls (n = 71), in order to testify whether metal levels may have a significant impact on the association between oxysterols and diabetes. Methods: Plasma trace elements and plasma oxysterols were assessed using atomic absorption spectrometry and LC-MS/MS, respectively. Lifestyle, smoking status, alcohol intake, and drug usage, as well as microvascular complications, were also monitored and reported. Results: The obtained data demonstrated that both DM1 and DM2 patients were characterized by significantly elevated HbA1c, FBG, TC, LDL-C, VLDL-C, and TG levels as compared to controls. Plasma Zn levels and Zn/Cu ratio in DM1 and DM2 patients were about 3- and 2-fold lower than controls. No significant differences in plasma Cu levels were reported. The 7-ketocholesterol (7-kchol) le