Rationale and design of two prospective, multicenter, observational studies on reproductive outcome in women with recurrent failures after...
Villani M., Baldini D., Totaro P., Larciprete G., Kovac M., Carone D., Passamonti S. M., Permunian E. T., Bartolotti T., Lojacono A., Cacciola R., Pinto G. L., Bucherini E., De S. V., Lodigiani C., Lavopa C., Cho Y. S., Pizzicaroli C., Colaizzo D., Grandone E`.
BMC Pregnancy and Childbirth
Vol.19, Issue1, Num.292
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1186/s12884-019-2444-y
Аннотация:
Background: Spontaneous pregnancy loss and implantation failure after assisted reproductive technologies (ART) are very common occurrences. Although 50-60[%] of all cases remains unexplained, various predisposing factors, including thrombophilias, have been identified. Thus, the potential benefit of a prophylaxis with low-molecular-weight heparins in improving outcomes has been often investigated over the years. However, the majority of studies are observational and results from randomized clinical trials (RCTs) are inconclusive, probably due to heterogeneity and limited sample size. To cover these unmet needs and to have further data mainly based on the real-life clinical management, we designed these multicenter registries. Methods: OTTILIA (Observational sTudy on antiThrombotic prevention in thrombophILIA and pregnancy loss) and FIRST (recurrent Failures in assIsted Reproductive Techniques) registries are two prospective, multicenter, observational studies to evaluate pregnancy or ART
Ключевые слова:
Assisted reproductive technologies; Heparins; Implantation failure; Observational study; Pregnancy loss; Risk factors; Thrombophilia
Article; clinical practice; disease registry; female; fetus; follow up; health care need; human; human tissue; infertility therapy; length of stay; live birth; multicenter study; observational study; ovary hyperstimulation; practice guideline; pregnancy disorder; pregnancy outcome; pregnancy rate; prospective study; risk assessment; risk factor; spontaneous abortion; thrombosis prevention; clinical trial; pregnancy; recurrent abortion; register; thrombophilia; treatment failure; anticoagulant agent; low molecular weight heparin; Abortion, Habitual; Anticoagulants; Female; Heparin, Low-Molecular-Weight; Humans; Live Birth; Pregnancy; Pregnancy Rate; Prospective Studies; Registries; Reproductive Techniques, Assisted; Thrombophilia; Treatment Failure
Язык текста: Английский
ISSN: 1471-2393
Villani M.
Baldini D.
Totaro P.
Larciprete G.
Kovac M.
Carone D.
Passamonti S. M.
Permunian E. T.
Bartolotti T.
Lojacono A.
Cacciola R.
Pinto G. L.
Bucherini E.
De S. V. Stefano V.
Lodigiani C.
Lavopa C.
Cho Y. S.
Pizzicaroli C.
Colaizzo D.
Grandone E`. E`l`vira 1963-
Виллани М.
Балдини Д.
Тотаро П.
Ларcипрете Г.
Коваc М.
Cароне Д.
Пассамонти С. М.
Пермуниан Е. Т.
Бартолотти Т.
Лойаcоно А.
Cаccиола Р.
Пинто Г. Л.
Бучерини Е.
Де С. В. Стефано В.
Лодигиани C.
Лавопа C.
Чо Y. С.
Пиззиcароли C.
Cолаиззо Д.
Грандоне Э. Эльвира 1963-
Rationale and design of two prospective, multicenter, observational studies on reproductive outcome in women with recurrent failures after spontaneous or assisted conception: OTTILIA and FIRST registries
Rationale and design of two prospective, multicenter, observational studies on reproductive outcome in women with recurrent failures after...
Текст визуальный непосредственный
BMC Pregnancy and Childbirth
BioMed Central Ltd.
Vol.19, Issue1 Num.292
2019
Статья
Assisted reproductive technologies Heparins Implantation failure Observational study Pregnancy loss Risk factors Thrombophilia
Article clinical practice disease registry female fetus follow up health care need human human tissue infertility therapy length of stay live birth multicenter study observational study ovary hyperstimulation practice guideline pregnancy disorder pregnancy outcome pregnancy rate prospective study risk assessment risk factor spontaneous abortion thrombosis prevention clinical trial pregnancy recurrent abortion register thrombophilia treatment failure anticoagulant agent low molecular weight heparin Abortion, Habitual Anticoagulants Female Heparin, Low-Molecular-Weight Humans Live Birth Pregnancy Pregnancy Rate Prospective Studies Registries Reproductive Techniques, Assisted Thrombophilia Treatment Failure
Background: Spontaneous pregnancy loss and implantation failure after assisted reproductive technologies (ART) are very common occurrences. Although 50-60[%] of all cases remains unexplained, various predisposing factors, including thrombophilias, have been identified. Thus, the potential benefit of a prophylaxis with low-molecular-weight heparins in improving outcomes has been often investigated over the years. However, the majority of studies are observational and results from randomized clinical trials (RCTs) are inconclusive, probably due to heterogeneity and limited sample size. To cover these unmet needs and to have further data mainly based on the real-life clinical management, we designed these multicenter registries. Methods: OTTILIA (Observational sTudy on antiThrombotic prevention in thrombophILIA and pregnancy loss) and FIRST (recurrent Failures in assIsted Reproductive Techniques) registries are two prospective, multicenter, observational studies to evaluate pregnancy or ART