Reviewing the evidence on breast milk composition and immunological outcomes
Boix-Amorós A., Collado M. C., Van't L. B., Calvert A., Le D. K., Garssen J., Hanna H., Khaleva E., Peroni D. G., Geddes D. T., Kozyrskyj A. L., Warner J. O., Munblit D. B.
Nutrition Reviews
Vol.77, Issue8, Num.nuz019
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1093/nutrit/nuz019
Аннотация:
A large number of biologically active components have been found in human milk (HM), and in both human and animal models, studies have provided some evidence suggesting that HM composition can be altered by maternal exposures, subsequently influencing health outcomes for the breastfed child. Evidence varies from the research studies on whether breastfeeding protects the offspring from noncommunicable diseases, including those associated with immunological dysfunction. It has been hypothesized that the conflicting evidence results from HM composition variations, which contain many immune active molecules, oligosaccharides, lactoferrin, and lysozyme in differing concentrations, along with a diverse microbiome. Determining the components that influence infant health outcomes in terms of both short- and long-term sequelae is complicated by a lack of understanding of the environmental factors that modify HM constituents and thereby offspring outcomes. Variations in HM immune and microbial c
Ключевые слова:
antibiotics; breast milk; human milk; immune active molecules; immunological outcomes; microbiome; oligosaccharides; vaccine response
BCG vaccine; diphtheria vaccine; Haemophilus influenzae type b vaccine; immunoglobulin A; lactoferrin; oligosaccharide; prebiotic agent; Rotavirus vaccine; antibiotic therapy; antibody response; Article; breast milk; child health; environmental factor; gastrointestinal tract; human; immunology; infant nutrition; intestine flora; maternal exposure; maternal welfare; microbial community; microbial interaction; mouth cavity; mouth flora; non communicable disease; nonhuman; skin flora; clinical outcome; microflora; skin
Язык текста: Английский
ISSN: 1753-4887
Boix-Amorós A.
Collado M. C.
Van't L. B. Land B.
Calvert A.
Le D. K. Doare K.
Garssen J.
Hanna H.
Khaleva E.
Peroni D. G.
Geddes D. T.
Kozyrskyj A. L.
Warner J. O.
Munblit D. B. Daniil Borisovich 1980-
Боих-Аморóс А.
Cолладо М. C.
Ван'т Л. Б. Ланд Б.
Cалверт А.
Ле Д. К. Доаре К.
Гарссен Й.
Ханна Х.
Халева Е.
Перони Д. Г.
Геддес Д. Т.
Козyрскyй А. Л.
Wарнер Й. О.
Мунблит Д. Б. Даниил Борисович 1980-
Reviewing the evidence on breast milk composition and immunological outcomes
Текст визуальный непосредственный
Nutrition Reviews
Proquest Academic Research Library
Vol.77, Issue8 Num.nuz019
2019
Статья
antibiotics breast milk human milk immune active molecules immunological outcomes microbiome oligosaccharides vaccine response
BCG vaccine diphtheria vaccine Haemophilus influenzae type b vaccine immunoglobulin A lactoferrin oligosaccharide prebiotic agent Rotavirus vaccine antibiotic therapy antibody response Article breast milk child health environmental factor gastrointestinal tract human immunology infant nutrition intestine flora maternal exposure maternal welfare microbial community microbial interaction mouth cavity mouth flora non communicable disease nonhuman skin flora clinical outcome microflora skin
A large number of biologically active components have been found in human milk (HM), and in both human and animal models, studies have provided some evidence suggesting that HM composition can be altered by maternal exposures, subsequently influencing health outcomes for the breastfed child. Evidence varies from the research studies on whether breastfeeding protects the offspring from noncommunicable diseases, including those associated with immunological dysfunction. It has been hypothesized that the conflicting evidence results from HM composition variations, which contain many immune active molecules, oligosaccharides, lactoferrin, and lysozyme in differing concentrations, along with a diverse microbiome. Determining the components that influence infant health outcomes in terms of both short- and long-term sequelae is complicated by a lack of understanding of the environmental factors that modify HM constituents and thereby offspring outcomes. Variations in HM immune and microbial c