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Allocation of liver grafts worldwide – Is there a best system?

Tschuor C., Ferrarese A., Kuemmerli C., Dutkowski P., Burra P., Clavien P. -., Lendoire J., Imventarza O., Crawford M., Andraus W., D'Albuquerque L. A. C., Hernandez-Alejandro R., Dokus M. K., Tomiyama K., Zheng S., Echeverri G. J., Taimr P., Fronek J., de R. R. M., Vogelaar S., Lesurtel M., Mabrut J. -., Nagral S., Kakaei F., Malek-Hosseini S. A., Egawa H., Contreras A., Czerwinski J., Danek T., Pinto-Marques H., Gotye S. V., Monakhov A. R., Melum E., Ericzon B. -., Kang K. J., Kim M. S., Sanchez-Velazquez P., Oberkofler C. E., Müllhaupt B., Linecker M., Eshmuminov D., Grochola L. F., Song Z., Kambakamba P., Chen C. -., Haberal M., Yilmaz S., Rowe I. A. C., Kron P.
Journal of Hepatology
Vol.71, Issue4, P. 707-718
Опубликовано: 2019
Тип ресурса: Статья

DOI:10.1016/j.jhep.2019.05.025

Аннотация:
Background & Aims: An optimal allocation system for scarce resources should simultaneously ensure maximal utility, but also equity. The most frequent principles for allocation policies in liver transplantation are therefore criteria that rely on pre-transplant survival (sickest first policy), post-transplant survival (utility), or on their combination (benefit). However, large differences exist between centers and countries for ethical and legislative reasons. The aim of this study was to report the current worldwide practice of liver graft allocation and discuss respective advantages and disadvantages. Methods: Countries around the world that perform 95 or more deceased donor liver transplantations per year were analyzed for donation and allocation policies, as well as recipient characteristics. Results: Most countries use the model for end-stage liver disease (MELD) score, or variations of it, for organ allocation, while some countries opt for center-based allocation systems based on
Ключевые слова:
Allocation; ELTR; Liver transplantation; MELD; Organ donation; UNOS
Article; benchmarking; bile duct carcinoma; deceased donor; disease risk assessment; end stage liver disease; graft recipient; graft survival; health care cost; health care policy; health care system; hospital admission; human; intensive care unit; international normalized ratio; liver cell carcinoma; liver graft; liver transplantation; Model For End Stage Liver Disease Score; morbidity; portal hypertension; priority journal; probability; prothrombin time; survival rate; transjugular intrahepatic portosystemic shunt; adult; article; death; recipient; surgery
Язык текста: Английский
ISSN: 1600-0641
Tschuor C.
Ferrarese A.
Kuemmerli C.
Dutkowski P.
Burra P.
Clavien P. -. P.-A.
Lendoire J.
Imventarza O.
Crawford M.
Andraus W.
D'Albuquerque L. A. C.
Hernandez-Alejandro R.
Dokus M. K.
Tomiyama K.
Zheng S.
Echeverri G. J.
Taimr P.
Fronek J.
de R. R. M. Rosner-van Rosmalen M.
Vogelaar S.
Lesurtel M.
Mabrut J. -. J.-Y.
Nagral S.
Kakaei F.
Malek-Hosseini S. A.
Egawa H.
Contreras A.
Czerwinski J.
Danek T.
Pinto-Marques H.
Gotye S. V. Sergej Vladimirovich 1947-
Monakhov A. R. Artem Rashidovich 1987-
Melum E.
Ericzon B. -. B.-G.
Kang K. J.
Kim M. S.
Sanchez-Velazquez P.
Oberkofler C. E.
Müllhaupt B.
Linecker M.
Eshmuminov D.
Grochola L. F.
Song Z.
Kambakamba P.
Chen C. -. C.-L.
Haberal M.
Yilmaz S.
Rowe I. A. C.
Kron P.
Цчуор C.
Ферраресе А.
Куеммерли C.
Дуткоwски П.
Бурра П.
Cлавиен П. -. П.-А.
Лендоире Й.
Имвентарза О.
Cраwфорд М.
Андраус W.
Д'Албуqуерqуе Л. А. C.
Хернандез-Алейандро Р.
Докус М. К.
Томияма К.
Женг С.
Ечеверри Г. Й.
Таимр П.
Фронек Й.
де Р. Р. М. Роснер-ван Росмален М.
Вогелаар С.
Лесуртел М.
Мабрут Й. -. Й.-Y.
Награл С.
Какаеи Ф.
Малек-Хоссеини С. А.
Егаwа Х.
Cонтрерас А.
Cзерwински Й.
Данек Т.
Пинто-Марqуес Х.
Готье С. В. Сергей Владимирович 1947-
Монахов А. Р. Артем Рашидович 1987-
Мелум Е.
Ериcзон Б. -. Б.-Г.
Канг К. Й.
Ким М. С.
Санчез-Велазqуез П.
Оберкофлер C. Е.
Мüллхаупт Б.
Линеcкер М.
Ешмуминов Д.
Грочола Л. Ф.
Сонг З.
Камбакамба П.
Чен C. -. C.-Л.
Хаберал М.
Yилмаз С.
Роwе И. А. C.
Крон П.
Allocation of liver grafts worldwide – Is there a best system?
Текст визуальный непосредственный
Journal of Hepatology
Elsevier Science Publisher B.V.
Vol.71, Issue4 P. 707-718
2019
Статья
Allocation ELTR Liver transplantation MELD Organ donation UNOS
Article benchmarking bile duct carcinoma deceased donor disease risk assessment end stage liver disease graft recipient graft survival health care cost health care policy health care system hospital admission human intensive care unit international normalized ratio liver cell carcinoma liver graft liver transplantation Model For End Stage Liver Disease Score morbidity portal hypertension priority journal probability prothrombin time survival rate transjugular intrahepatic portosystemic shunt adult article death recipient surgery
Background & Aims: An optimal allocation system for scarce resources should simultaneously ensure maximal utility, but also equity. The most frequent principles for allocation policies in liver transplantation are therefore criteria that rely on pre-transplant survival (sickest first policy), post-transplant survival (utility), or on their combination (benefit). However, large differences exist between centers and countries for ethical and legislative reasons. The aim of this study was to report the current worldwide practice of liver graft allocation and discuss respective advantages and disadvantages. Methods: Countries around the world that perform 95 or more deceased donor liver transplantations per year were analyzed for donation and allocation policies, as well as recipient characteristics. Results: Most countries use the model for end-stage liver disease (MELD) score, or variations of it, for organ allocation, while some countries opt for center-based allocation systems based on