Аннотация:
This review is devoted to a serious complication of Hirschsprung's disease in children – Hirschsprung-associated enterocolitis (HAEC) – inflammation of the intestine, which often has severe manifestations and may lead to death. The main causes of HAEC include gut microbiome changes, impaired barrier function of the intestinal mucosa, altered immune response, and bacterial translocation. Risk factors are male gender, trisomy 21, family forms of Hirschsprung's disease, extended area of aganglionosis, etc. Clinical manifestations include diarrhea, fever, and abdominal distention. The diagnosis should be based on clinical signs, results of ultrasound and X-ray examination of the abdominal cavity, and stool culture with drug susceptibility testing. Treatment of HAEC is usually initiated immediately after the onset of symptoms; it includes intestinal decompression as well as antibacterial and antimicrobial therapy. The risk of HAEC determines the need for timely surgical treatment of Hirschs
Ключевые слова:
Children; Hirschsprung's disease; Hirschsprung-associated enterocolitis
abdominal cavity; bacterial translocation; child; drug sensitivity; enterocolitis; feces culture; Hirschsprung disease; human; immune response; intestine flora; intestine mucosa; nonhuman; Review; risk factor; trisomy 21
Морозов Д. А. Дмитрий Анатольевич 1971-
Пименова Е. С. Евгения Сергеевна 1982-
Королев Г. А. Григорий Алексеевич 1996-
Morozov D. A. Dmitrij Anatolyevich 1971-
Pimenova E. S. Evgeniya Sergeevna 1982-
Korolev G. A. Grigorij Alekseevich 1996-
Hirschsprung-associated enterocolitis in children
Текст визуальный непосредственный
Вопросы практической педиатрии
ООО "Издательство "Династия"
Т. 14, Вып. 2 С. 35-42
2019
Обзор
Children Hirschsprung's disease Hirschsprung-associated enterocolitis
abdominal cavity bacterial translocation child drug sensitivity enterocolitis feces culture Hirschsprung disease human immune response intestine flora intestine mucosa nonhuman Review risk factor trisomy 21
This review is devoted to a serious complication of Hirschsprung's disease in children – Hirschsprung-associated enterocolitis (HAEC) – inflammation of the intestine, which often has severe manifestations and may lead to death. The main causes of HAEC include gut microbiome changes, impaired barrier function of the intestinal mucosa, altered immune response, and bacterial translocation. Risk factors are male gender, trisomy 21, family forms of Hirschsprung's disease, extended area of aganglionosis, etc. Clinical manifestations include diarrhea, fever, and abdominal distention. The diagnosis should be based on clinical signs, results of ultrasound and X-ray examination of the abdominal cavity, and stool culture with drug susceptibility testing. Treatment of HAEC is usually initiated immediately after the onset of symptoms; it includes intestinal decompression as well as antibacterial and antimicrobial therapy. The risk of HAEC determines the need for timely surgical treatment of Hirschs