Serum levels of copper, iron, and manganese in women with pregnancy, miscarriage, and primary infertility
Skal`naya M. G., Tin`kov A. A., Lobanova Y. N., Chang J. -., Skal`ny'j A. V.
Journal of Trace Elements in Medicine and Biology
Vol.56, P. 124-130
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.jtemb.2019.08.009
Аннотация:
Background: Iron (Fe), copper (Cu), and manganese (Mn) play a significant role in female reproduction and fetal development. At the same time, high levels of metals may exert toxic effects. Correspondingly, both excess and deficiency of essential trace elements were shown to be associated with female infertility and adverse pregnancy outcome, although the existing data are rather contradictory. Therefore, the objective of the present study was to reveal the potential role of altered iron, copper, and manganese status in female reproductive health problems through assessment of serum metal levels in healthy non-pregnant and pregnant women, as well as patients with miscarriage and primary infertility. Methods: A total of 150 healthy controls, 169 pregnant women (II trimester of pregnancy), 75 women with miscarriage, and 91 patients with primary infertility were enrolled. Serum metal levels were assessed using ICP-MS. Results: Pregnant women are characterized by a significant increase in
Ключевые слова:
Copper; Manganese; Pregnancy; Pregnancy outcome; Reproduction
copper; iron; manganese; copper; iron; manganese; adult; anthropometric parameters; Article; cohort analysis; controlled study; copper blood level; female; female infertility; human; inductively coupled plasma mass spectrometry; iron blood level; major clinical study; manganese blood level; priority journal; second trimester pregnancy; spontaneous abortion; blood; body mass; female infertility; pregnancy; quality control; reproduction; spontaneous abortion; statistical model; Abortion, Spontaneous; Adult; Body Mass Index; Copper; Female; Humans; Infertility, Female; Iron; Linear Models; Manganese; Pregnancy; Quality Control; Reproduction
Язык текста: Английский
ISSN: 0946-672X
Skal`naya M. G. Margarita Gennadievna 1968-
Tin`kov A. A. Aleksej Alekseevich 1989-
Lobanova Y. N.
Chang J. -. J.-S.
Skal`ny'j A. V. Anatolij Viktorovich 1962-
Скальная М. Г. Маргарита Геннадиевна 1968-
Тиньков А. А. Алексей Алексеевич 1989-
Лобанова Y. Н.
Чанг Й. -. Й.-С.
Скальный А. В. Анатолий Викторович 1962-
Serum levels of copper, iron, and manganese in women with pregnancy, miscarriage, and primary infertility
Текст визуальный непосредственный
Journal of Trace Elements in Medicine and Biology
Urban & Fischer
Vol.56 P. 124-130
2019
Статья
Copper Manganese Pregnancy Pregnancy outcome Reproduction
copper iron manganese copper iron manganese adult anthropometric parameters Article cohort analysis controlled study copper blood level female female infertility human inductively coupled plasma mass spectrometry iron blood level major clinical study manganese blood level priority journal second trimester pregnancy spontaneous abortion blood body mass female infertility pregnancy quality control reproduction spontaneous abortion statistical model Abortion, Spontaneous Adult Body Mass Index Copper Female Humans Infertility, Female Iron Linear Models Manganese Pregnancy Quality Control Reproduction
Background: Iron (Fe), copper (Cu), and manganese (Mn) play a significant role in female reproduction and fetal development. At the same time, high levels of metals may exert toxic effects. Correspondingly, both excess and deficiency of essential trace elements were shown to be associated with female infertility and adverse pregnancy outcome, although the existing data are rather contradictory. Therefore, the objective of the present study was to reveal the potential role of altered iron, copper, and manganese status in female reproductive health problems through assessment of serum metal levels in healthy non-pregnant and pregnant women, as well as patients with miscarriage and primary infertility. Methods: A total of 150 healthy controls, 169 pregnant women (II trimester of pregnancy), 75 women with miscarriage, and 91 patients with primary infertility were enrolled. Serum metal levels were assessed using ICP-MS. Results: Pregnant women are characterized by a significant increase in