Аннотация:
Preterm birth is not only medical, but also a social problem. The global goal of medicine is prevention of preterm labor and identification of risk factors leading to preterm birth. The objective of our study was to find the association between polymorphic markers in the cytokine IL-β, TNF-α, IL-1Ra, and IL-4 genes and development of preterm labor. The prospective study was conducted in 108 pregnant women with the risk of preterm birth. The main group consisted of 66 women whose pregnancy ended with preterm delivery despite the ongoing therapy. The comparison group included 42 women with the full-term delivery. The dominant T allele of the cytokine IL-1β gene polymorphism rs1143634 (3953C→T) was 7.6 times more common in women with preterm delivery vs. the comparison group (36.4 and 4.8[%], respectively; RR, 1.802; 95[%] CI, 1.420–2.288; p < 0.05); its homozygous form was detected only in women with preterm delivery at the very early gestation age (less than 26 weeks). The dominant proinfla
Ключевые слова:
cytokine gene polymorphism; cytokines; IL-1Ra; IL-1β; IL-4; IL-4; interleukins; preterm labor; TNF-α
IL4 protein, human; interleukin 1 receptor blocking agent; interleukin 1beta; interleukin 4; tumor necrosis factor; allele; female; genetic polymorphism; genetics; human; pregnancy; prematurity; prospective study; risk factor; Alleles; Female; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Interleukin-4; Polymorphism, Genetic; Pregnancy; Premature Birth; Prospective Studies; Risk Factors; Tumor Necrosis Factors
Belousova V. S. Vera Sergeevna 1977-
Svitich O. A. Oksana Anatolyevna 1979-
Timokhina E. V. Elena Vladimirovna 1974-
Strizhakov A. N. Aleksandr Nikolaevich 1937-
Bogomazova I. M. Irina Mikhaylovna 1979-
Белоусова В. С. Вера Сергеевна 1977-
Свитич О. А. Оксана Анатольевна 1979-
Тимохина Е. В. Елена Владимировна 1974-
Стрижаков А. Н. Александр Николаевич 1937-
Богомазова И. М. Ирина Михайловна 1979-
Polymorphism of the IL-1β, TNF, IL-1RA and IL-4 Cytokine Genes Significantly Increases the Risk of Preterm Birth
Текст визуальный непосредственный
Biochemistry (Moscow)
Pleiades Publishing, Ltd.
Vol.84, Issue9 P. 1040-1046
2019
Статья
cytokine gene polymorphism cytokines IL-1Ra IL-1β IL-4 IL-4 interleukins preterm labor TNF-α
IL4 protein, human interleukin 1 receptor blocking agent interleukin 1beta interleukin 4 tumor necrosis factor allele female genetic polymorphism genetics human pregnancy prematurity prospective study risk factor Alleles Female Humans Interleukin 1 Receptor Antagonist Protein Interleukin-1beta Interleukin-4 Polymorphism, Genetic Pregnancy Premature Birth Prospective Studies Risk Factors Tumor Necrosis Factors
Preterm birth is not only medical, but also a social problem. The global goal of medicine is prevention of preterm labor and identification of risk factors leading to preterm birth. The objective of our study was to find the association between polymorphic markers in the cytokine IL-β, TNF-α, IL-1Ra, and IL-4 genes and development of preterm labor. The prospective study was conducted in 108 pregnant women with the risk of preterm birth. The main group consisted of 66 women whose pregnancy ended with preterm delivery despite the ongoing therapy. The comparison group included 42 women with the full-term delivery. The dominant T allele of the cytokine IL-1β gene polymorphism rs1143634 (3953C→T) was 7.6 times more common in women with preterm delivery vs. the comparison group (36.4 and 4.8[%], respectively; RR, 1.802; 95[%] CI, 1.420–2.288; p < 0.05); its homozygous form was detected only in women with preterm delivery at the very early gestation age (less than 26 weeks). The dominant proinfla