Levels of pro-inflammatory and anti-inflammatory cytokines and interferons in pregnant women with vaginal infections during vitamin D therapy
Костинов М. П., Игнат’ева М. А., Новикова С. В., Шмит’ко А. Д., Полишчук В. Б., Савис’ко А. А.
Акушерство и гинекология
Т. 2019, Вып. 9, С. 75-81
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.18565/aig.2019.9.75-81
Аннотация:
Aim. To investigate the effect of vitamin D supplementation on pro/anti-inflammatory cytokines and interferons in pregnant women with vaginal infections. Materials and methods. We analyzed serum levels of 25-hydroxyvitamin D, cytokines, and interferons in 72 pregnant women using ELISA. Results. Vitamin D supplementation was associated with a decrease in the levels of pro-inflammatory cytokines including IL-8 from 22.27 ± 9.21 pg/ml to 19.21 ± 5.11 pg/ml and IL-1β from 0.36 ± 0.2 pg/ml to 0 ± 0 pg/ml while IFN-γ level increased from 0.36 ± 0.36 pg/ml to 1.19 ± 0.61 pg/ml. The incidence rate of ARI in pregnant women supplemented with vitamin D was 13 times lower (3.4[%] versus 44.2[%]) than that in pregnant women who did not receive specific therapy. Conclusion. In pregnant women with vaginal infections, vitamin D supplementation beginning from the second trimester of pregnancy affects the levels of pro/anti-inflammatory cytokines, interferons, and susceptibility to ARI. © 2019, Bionika Medi
Ключевые слова:
Cytokines; Interferons; Vaginal infections; Vitamin D
25 hydroxyvitamin D; cytokine; gamma interferon; interferon; interleukin 1beta; interleukin 8; Article; clinical assessment; drug effect; enzyme linked immunosorbent assay; female; human; incidence; pregnant woman; protein blood level; vaginitis; vitamin supplementation
Язык текста: Русский
ISSN: 0300-9092
Костинов М. П. Михаил Петрович 1956-
Игнат’ева М. А.
Новикова С. В.
Шмит’ко А. Д.
Полишчук В. Б.
Савис’ко А. А.
Kostinov M. P. Mikhail Petrovich 1956-
Ignat’eva M. A.
Novikova S. V.
Shmit’ko A. D.
Polishchuk V. B.
Savis’ko A. A.
Levels of pro-inflammatory and anti-inflammatory cytokines and interferons in pregnant women with vaginal infections during vitamin D therapy
Текст визуальный непосредственный
Акушерство и гинекология
Бионика Медиа
Т. 2019, Вып. 9 С. 75-81
2019
Статья
Cytokines Interferons Vaginal infections Vitamin D
25 hydroxyvitamin D cytokine gamma interferon interferon interleukin 1beta interleukin 8 Article clinical assessment drug effect enzyme linked immunosorbent assay female human incidence pregnant woman protein blood level vaginitis vitamin supplementation
Aim. To investigate the effect of vitamin D supplementation on pro/anti-inflammatory cytokines and interferons in pregnant women with vaginal infections. Materials and methods. We analyzed serum levels of 25-hydroxyvitamin D, cytokines, and interferons in 72 pregnant women using ELISA. Results. Vitamin D supplementation was associated with a decrease in the levels of pro-inflammatory cytokines including IL-8 from 22.27 ± 9.21 pg/ml to 19.21 ± 5.11 pg/ml and IL-1β from 0.36 ± 0.2 pg/ml to 0 ± 0 pg/ml while IFN-γ level increased from 0.36 ± 0.36 pg/ml to 1.19 ± 0.61 pg/ml. The incidence rate of ARI in pregnant women supplemented with vitamin D was 13 times lower (3.4[%] versus 44.2[%]) than that in pregnant women who did not receive specific therapy. Conclusion. In pregnant women with vaginal infections, vitamin D supplementation beginning from the second trimester of pregnancy affects the levels of pro/anti-inflammatory cytokines, interferons, and susceptibility to ARI. © 2019, Bionika Medi