Statistical approaches in the studies assessing associations between human milk immune composition and allergic diseases: A scoping review
Blyuss O., Cheung K. Y., Chen J., Parr C., Petrou L., Komarova A., Kokina M. Yu., Luzan P. Yu., Pas`ko E. T., Eremeeva A. V., Peshko D. A., Eliseev V. I., Pedersen S. A., Azad M. B., Jarvinen K. M., Peroni D. G., Verhasselt V., Boyle R. J., Warner J. O., Simpson M. R., Munblit D. B.
Nutrients
Vol.11, Issue10, Num.2416
Опубликовано: 2019
Тип ресурса: Статья
Аннотация:
A growing number of studies are focusing on the associations between human milk (HM) immunological composition and allergic diseases. This scoping review aims to identify statistical methods applied in the field and highlight pitfalls and unmet needs. A comprehensive literature search in MEDLINE and Embase retrieved 13,607 unique records. Following title/abstract screening, 29 studies met the selection criteria and were included in this review. We found that definitions of colostrum and mature milk varied across the studies. A total of 17 out of 29 (59[%]) studies collected samples longitudinally, but only 12[%] of these used serial (longitudinal) analyses. Multivariable analysis was used in 45[%] of the studies, but statistical approaches to modelling varied largely across the studies. Types of variables included as potential confounding factors differed considerably between models. Discrimination analysis was absent from all studies and only a single study reported classification measures.
Ключевые слова:
Allergy; Breast milk; Colostrum; Human milk; Immune composition; Immune markers; Longitudinal algorithms; Methodology; Serial analysis; Statistical analysis
allergic disease; area under the curve; Article; breast milk; cancer screening; disease activity; disease association; food allergy; human; immune adherence; intestine flora; lactation; meta analysis; mother child relation; outcome assessment; puerperium; screening test; sensitivity and specificity; sensitization; systematic review; algorithm; chemistry; colostrum; epidemiology; female; hypersensitivity; immunology; pathophysiology; statistical model; biological marker; Algorithms; Biomarkers; Colostrum; Epidemiologic Methods; Female; Humans; Hypersensitivity; Milk, Human; Models, Statistical; Systematic Reviews as Topic
Язык текста: Английский
ISSN: 2072-6643
Blyuss O. Oleg 1985-
Cheung K. Y.
Chen J.
Parr C.
Petrou L.
Komarova A.
Kokina M. Yu. Mariya Yuryevna 1996-
Luzan P. Yu. Polina Yuryevna 1996-
Pas`ko E. T. Egor Timurovich 1996-
Eremeeva A. V. Alina Vladimirovna 1974-
Peshko D. A. Dmitrij Alekseevich 1995-
Eliseev V. I.
Pedersen S. A.
Azad M. B.
Jarvinen K. M.
Peroni D. G.
Verhasselt V.
Boyle R. J.
Warner J. O.
Simpson M. R.
Munblit D. B. Daniil Borisovich 1980-
Блюсс О. Олег 1985-
Чеунг К. Y.
Чен Й.
Парр C.
Петроу Л.
Комарова А.
Кокина М. Ю. Мария Юрьевна 1996-
Лузан П. Ю. Полина Юрьевна 1996-
Пасько Е. Т. Егор Тимурович 1996-
Еремеева А. В. Алина Владимировна 1974-
Пешко Д. А. Дмитрий Алексеевич 1995-
Елисеев В. И.
Педерсен С. А.
Азад М. Б.
Йарвинен К. М.
Перони Д. Г.
Верхасселт В.
Боyле Р. Й.
Wарнер Й. О.
Симпсон М. Р.
Мунблит Д. Б. Даниил Борисович 1980-
Statistical approaches in the studies assessing associations between human milk immune composition and allergic diseases: A scoping review
Текст визуальный непосредственный
Nutrients
Vol.11, Issue10 Num.2416
2019
Статья
Allergy Breast milk Colostrum Human milk Immune composition Immune markers Longitudinal algorithms Methodology Serial analysis Statistical analysis
allergic disease area under the curve Article breast milk cancer screening disease activity disease association food allergy human immune adherence intestine flora lactation meta analysis mother child relation outcome assessment puerperium screening test sensitivity and specificity sensitization systematic review algorithm chemistry colostrum epidemiology female hypersensitivity immunology pathophysiology statistical model biological marker Algorithms Biomarkers Colostrum Epidemiologic Methods Female Humans Hypersensitivity Milk, Human Models, Statistical Systematic Reviews as Topic
A growing number of studies are focusing on the associations between human milk (HM) immunological composition and allergic diseases. This scoping review aims to identify statistical methods applied in the field and highlight pitfalls and unmet needs. A comprehensive literature search in MEDLINE and Embase retrieved 13,607 unique records. Following title/abstract screening, 29 studies met the selection criteria and were included in this review. We found that definitions of colostrum and mature milk varied across the studies. A total of 17 out of 29 (59[%]) studies collected samples longitudinally, but only 12[%] of these used serial (longitudinal) analyses. Multivariable analysis was used in 45[%] of the studies, but statistical approaches to modelling varied largely across the studies. Types of variables included as potential confounding factors differed considerably between models. Discrimination analysis was absent from all studies and only a single study reported classification measures.