Cefotaxime/sulbactam: An important addition to the arsenal of inhibitor-protected beta-lactam antibiotics
Яковиев С. В., Суворова М. П.
Антибиотики и химиотерапия
Т. 64, Вып. 3-4, С. 71-80
Опубликовано: 2019
Тип ресурса: Статья
Аннотация:
A new inhibitor-protected beta-lactam antibiotic has been registered In Russia, a fixed combination of antistreptococcal cephalosporin III, cefotaxime and inhibitor of beta-lactamase sulbactam in a 2:1 ratio. TTie antimicrobial spectrum of cefotaxime/sulbactam combines the high activity of protected aminopenicillins against gram-positive bacteria and the high activity of protected cephalosporins against enterobacteria. Fur tbermore due to the addition of sulbactam, cefotaxime/sulbactam's antimicrobial activity spectrum also includes one of the leading infectious agents in the ICU-Acinetobacter baumannii. Adding sulbactam to cefotaxime leads to a two-fold decrease in the IPCM of E.coli and K.pneumoniae, and even more pronounced decrease in P.mirabilis. The frequency of resistant strains of K.pneumoniae, E.cloaceae, S.marcescens, and A.baumannii significantly (3-10 times) decreases when combining cefotaxime with sulbactam in a 2:1 ratio compared to cefotaxime without an Inhibitor. Tie hi
Ключевые слова:
Antibacterial therapy; Cefotaxime; Inhibitor-protected beta-lactams; Resistance; Sulbactam
cefotaxime; sulbactam; Acinetobacter baumannii; antibacterial activity; Article; bacterial strain; community acquired infection; Escherichia coli; hospital infection; Klebsiella pneumoniae; nonhuman; peritonitis; pneumonia; Proteus mirabilis; Pseudomonas aeruginosa; Serratia marcescens; skin infection; soft tissue infection; urinary tract infection
Язык текста: Русский
ISSN: 0235-2990
Яковиев С. В.
Суворова М. П. Маргарита Петровна 1969-
Yakoviev S. V.
Suvorova M. P. Margarita Petrovna 1969-
Cefotaxime/sulbactam: An important addition to the arsenal of inhibitor-protected beta-lactam antibiotics
Текст визуальный непосредственный
Антибиотики и химиотерапия
Издательство ОКИ
Т. 64, Вып. 3-4 С. 71-80
2019
Статья
Antibacterial therapy Cefotaxime Inhibitor-protected beta-lactams Resistance Sulbactam
cefotaxime sulbactam Acinetobacter baumannii antibacterial activity Article bacterial strain community acquired infection Escherichia coli hospital infection Klebsiella pneumoniae nonhuman peritonitis pneumonia Proteus mirabilis Pseudomonas aeruginosa Serratia marcescens skin infection soft tissue infection urinary tract infection
A new inhibitor-protected beta-lactam antibiotic has been registered In Russia, a fixed combination of antistreptococcal cephalosporin III, cefotaxime and inhibitor of beta-lactamase sulbactam in a 2:1 ratio. TTie antimicrobial spectrum of cefotaxime/sulbactam combines the high activity of protected aminopenicillins against gram-positive bacteria and the high activity of protected cephalosporins against enterobacteria. Fur tbermore due to the addition of sulbactam, cefotaxime/sulbactam's antimicrobial activity spectrum also includes one of the leading infectious agents in the ICU-Acinetobacter baumannii. Adding sulbactam to cefotaxime leads to a two-fold decrease in the IPCM of E.coli and K.pneumoniae, and even more pronounced decrease in P.mirabilis. The frequency of resistant strains of K.pneumoniae, E.cloaceae, S.marcescens, and A.baumannii significantly (3-10 times) decreases when combining cefotaxime with sulbactam in a 2:1 ratio compared to cefotaxime without an Inhibitor. Tie hi