Rational MD simulations for improvement the affinity of nanobody against PlGF (placenta growth factor): mutagenesis based on electrostatic...
Forouzesh M., Askerovich M. A., Pourabadeh A., Hosseini M., Hosseinzadeh G., Arezumand R.
Journal of Biomolecular Structure and Dynamics
Vol.38, Issue12, P. 3750-3756
Опубликовано: 2020
Тип ресурса: Письмо
DOI:10.1080/07391102.2019.1664327
Аннотация:
AbbreviationsCOM center of mass distanceMD molecular dynamicsMM-PBSA Molecular Mechanics Poisson–Boltzmann Surface AreaNb nanobodyPlGF placenta growth factorRg radius of gyrationRMSD root mean-square deviationSASA solvent-accessible surface areaVEGF vascular endothelial growth factor. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Ключевые слова:
amino acid; nanobody; placental growth factor; antibody affinity; antibody structure; antigen binding; binding affinity; binding site; bioinformatics; complex formation; controlled study; hydrogen bond; Letter; molecular dynamics; molecular interaction; molecular stability; mutagenesis; mutational analysis; priority journal; protein binding; protein engineering; protein unfolding; static electricity; surface area; surface tension
Язык текста: Английский
ISSN: 1538-0254
Forouzesh M.
Askerovich M. A. Mamedov A.
Pourabadeh A.
Hosseini M.
Hosseinzadeh G.
Arezumand R.
Фороузеш М.
Аскерович М. А. Мамедов А.
Поурабадех А.
Хоссеини М.
Хоссеинзадех Г.
Арезуманд Р.
Rational MD simulations for improvement the affinity of nanobody against PlGF (placenta growth factor): mutagenesis based on electrostatic interactions
Rational MD simulations for improvement the affinity of nanobody against PlGF (placenta growth factor): mutagenesis based on electrostatic...
Текст визуальный непосредственный
Journal of Biomolecular Structure and Dynamics
Adenine Press
Vol.38, Issue12 P. 3750-3756
2020
Письмо
amino acid nanobody placental growth factor antibody affinity antibody structure antigen binding binding affinity binding site bioinformatics complex formation controlled study hydrogen bond Letter molecular dynamics molecular interaction molecular stability mutagenesis mutational analysis priority journal protein binding protein engineering protein unfolding static electricity surface area surface tension
AbbreviationsCOM center of mass distanceMD molecular dynamicsMM-PBSA Molecular Mechanics Poisson–Boltzmann Surface AreaNb nanobodyPlGF placenta growth factorRg radius of gyrationRMSD root mean-square deviationSASA solvent-accessible surface areaVEGF vascular endothelial growth factor. © 2019 Informa UK Limited, trading as Taylor & Francis Group.