Аннотация:
Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
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The role of cysteine cathepsins in cancer progression and drug resistance
Текст визуальный непосредственный
International Journal of Molecular Sciences
Vol.20, Issue14 Num.3602
2019
Обзор
Cancer progression Cysteine cathepsins Drug resistance
cathepsin cystatin C cystatin M gelatinase B lysosome associated membrane protein 1 matrix metalloproteinase 15 protein Bax protein bcl 2 proteinase reactive oxygen metabolite stromelysin transcription factor ZEB1 tumor necrosis factor antineoplastic agent cathepsin protein bcl 2 amino acid sequence angiogenesis autophagy cancer growth cell death DNA methylation enzyme localization gene expression gene locus glioblastoma head and neck cancer heterozygosity loss human metastasis phenotype protein degradation protein expression Review signal transduction squamous cell carcinoma tumor invasion tumor microenvironment upregulation animal chemistry classification drug effect drug resistance enzymology extracellular matrix gene expression regulation genetics lymph node metastasis lysosome metabolism molecular model neoplasm neovascularization (pathology) pathology protein conformation tumor cell line Animals Antineoplastic Agents Cath
Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.