A prediction rule for lack of achievement of inactive disease with methotrexate as the sole disease-modifying antirheumatic therapy in juvenile...
Bava C., Mongelli F., Pistorio A., Bertamino M., Bracciolini G., Dalprà S., Davì S., Lanni S., Muratore V., Pederzoli S., Rosina S., Schiappapietra B., Suffia C., Varnier G., Verazza S., Giancane G., Consolaro A., Ravelli A.
Pediatric Rheumatology
Vol.17, Issue1, Num.50
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1186/s12969-019-0355-0
Аннотация:
Background: To investigate the frequency of achievement of inactive disease (ID) in children with juvenile idiopathic arthritis (JIA) treated with methotrexate (MTX) as the sole disease-modifyng antirheumatic (DMARD) therapy and to develop a prediction model for lack of attainment of ID. Methods: The clinical charts of consecutive patients started with MTX as the sole DMARD between 2000 and 2013 were reviewed. Patient follow-up was censored at first episode of ID or, in case ID was not reached, at last follow-up visit or when a biologic DMARD was prescribed. The characteristic at MTX start of patients who achieved or did not achieve ID were compared with univariate and multivariable analyses. Regression coefficients (β) of variables that entered the best-fitting logistic regression model were converted and summed to obtain a "prediction score" for lack of achievement of ID. Results: A total of 375 patients were included in the study. During MTX administration, 8.8[%] were given systemic
Ключевые слова:
Biologic therapies; Juvenile idiopathic arthritis; Methotrexate; Pediatric rheumatology; Prediction rule; Predictors
C reactive protein; corticosteroid; methotrexate; antirheumatic agent; methotrexate; arthritis; Article; child; controlled study; corticosteroid therapy; disease activity; enthesitis; enthesitis related arthritis; female; follow up; human; inactive disease; juvenile rheumatoid arthritis; major clinical study; male; medical record review; polyarthritis; prediction; predictive value; prescription; priority journal; protein blood level; systemic arthritis; systemic therapy; treatment duration; treatment outcome; epidemiology; juvenile rheumatoid arthritis; preschool child; treatment outcome; Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Treatment Outcome
Язык текста: Английский
ISSN: 1546-0096
Bava C.
Mongelli F.
Pistorio A.
Bertamino M.
Bracciolini G.
Dalprà S.
Davì S.
Lanni S.
Muratore V.
Pederzoli S.
Rosina S.
Schiappapietra B.
Suffia C.
Varnier G.
Verazza S.
Giancane G.
Consolaro A.
Ravelli A. Anzhelo 1956-
Бава C.
Монгелли Ф.
Писторио А.
Бертамино М.
Браccиолини Г.
Далпрà С.
Давì С.
Ланни С.
Мураторе В.
Педерзоли С.
Росина С.
Счиаппапиетра Б.
Суффиа C.
Варниер Г.
Веразза С.
Гианcане Г.
Cонсоларо А.
Равелли А. Анжело 1956-
A prediction rule for lack of achievement of inactive disease with methotrexate as the sole disease-modifying antirheumatic therapy in juvenile idiopathic arthritis
A prediction rule for lack of achievement of inactive disease with methotrexate as the sole disease-modifying antirheumatic therapy in juvenile...
Текст визуальный непосредственный
Pediatric Rheumatology
BioMed Central Ltd.
Vol.17, Issue1 Num.50
2019
Статья
Biologic therapies Juvenile idiopathic arthritis Methotrexate Pediatric rheumatology Prediction rule Predictors
C reactive protein corticosteroid methotrexate antirheumatic agent methotrexate arthritis Article child controlled study corticosteroid therapy disease activity enthesitis enthesitis related arthritis female follow up human inactive disease juvenile rheumatoid arthritis major clinical study male medical record review polyarthritis prediction predictive value prescription priority journal protein blood level systemic arthritis systemic therapy treatment duration treatment outcome epidemiology juvenile rheumatoid arthritis preschool child treatment outcome Antirheumatic Agents Arthritis, Juvenile Child Child, Preschool Epidemiologic Methods Female Humans Male Methotrexate Treatment Outcome
Background: To investigate the frequency of achievement of inactive disease (ID) in children with juvenile idiopathic arthritis (JIA) treated with methotrexate (MTX) as the sole disease-modifyng antirheumatic (DMARD) therapy and to develop a prediction model for lack of attainment of ID. Methods: The clinical charts of consecutive patients started with MTX as the sole DMARD between 2000 and 2013 were reviewed. Patient follow-up was censored at first episode of ID or, in case ID was not reached, at last follow-up visit or when a biologic DMARD was prescribed. The characteristic at MTX start of patients who achieved or did not achieve ID were compared with univariate and multivariable analyses. Regression coefficients (β) of variables that entered the best-fitting logistic regression model were converted and summed to obtain a "prediction score" for lack of achievement of ID. Results: A total of 375 patients were included in the study. During MTX administration, 8.8[%] were given systemic