Cross-protection of dengue virus infection against congenital Zika syndrome, northeastern Brazil
Pedroso C., Fischer C., Feldmann M., Sarno M., Luz E., Moreira-Soto A., Cabral R., Netto E. M., Brites C., Kümmerer B. M., Doktor D. Ya. F.
Emerging Infectious Diseases
Vol.25, Issue8, P. 1485-1493
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.3201/eid2508.190113
Аннотация:
The Zika virus outbreak in Latin America resulted in congenital malformations, called congenital Zika syndrome (CZS). For unknown reasons, CZS incidence was highest in northeastern Brazil; one potential explanation is that dengue virus (DENV)–mediated immune enhancement may promote CZS development. In contrast, our analyses of historical DENV genomic data refuted the hypothesis that unique genome signatures for northeastern Brazil explain the uneven dispersion of CZS cases. To confirm our findings, we performed serotype-specific DENV neutralization tests in a case–control framework in northeastern Brazil among 29 Zika virus–seropositive mothers of neonates with CZS and 108 Zika virus–seropositive control mothers. Neutralization titers did not differ significantly between groups. In contrast, DENV seroprevalence and median number of neutralized serotypes were significantly lower among the mothers of neonates with CZS. Supported by model analyses, our results suggest that multitypic DENV
Ключевые слова:
article; Brazil; clinical article; controlled study; cross protection; Dengue virus; female; human; mother; newborn; nonhuman; seroprevalence; serotype; virus neutralization; Zika virus; Brazil; classification; cross protection; dengue; Dengue virus; genetics; health survey; history; immunology; phylogeny; pregnancy; pregnancy complication; prevalence; prevention and control; time factor; vertical transmission; Zika fever; Brazil; Cross Protection; Dengue; Dengue Virus; Female; History, 20th Century; History, 21st Century; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Phylogeny; Pregnancy; Pregnancy Complications, Infectious; Prevalence; Public Health Surveillance; Serogroup; Time Factors; Zika Virus; Zika Virus Infection
Язык текста: Английский
ISSN: 1080-6059
Pedroso C.
Fischer C.
Feldmann M.
Sarno M.
Luz E.
Moreira-Soto A.
Cabral R.
Netto E. M.
Brites C.
Kümmerer B. M.
Doktor D. Ya. F. Dreksler Yan Feliks 1976-
Педросо C.
Фисчер C.
Фелдманн М.
Сарно М.
Луз Е.
Мореира-Сото А.
Cабрал Р.
Нетто Е. М.
Бритес C.
Кüммерер Б. М.
Доктор Д. Я. Ф. Дрекслер Ян Феликс 1976-
Cross-protection of dengue virus infection against congenital Zika syndrome, northeastern Brazil
Текст визуальный непосредственный
Emerging Infectious Diseases
US National Center for Infectious Diseases
Vol.25, Issue8 P. 1485-1493
2019
Статья
article Brazil clinical article controlled study cross protection Dengue virus female human mother newborn nonhuman seroprevalence serotype virus neutralization Zika virus Brazil classification cross protection dengue Dengue virus genetics health survey history immunology phylogeny pregnancy pregnancy complication prevalence prevention and control time factor vertical transmission Zika fever Brazil Cross Protection Dengue Dengue Virus Female History, 20th Century History, 21st Century Humans Infant, Newborn Infectious Disease Transmission, Vertical Phylogeny Pregnancy Pregnancy Complications, Infectious Prevalence Public Health Surveillance Serogroup Time Factors Zika Virus Zika Virus Infection
The Zika virus outbreak in Latin America resulted in congenital malformations, called congenital Zika syndrome (CZS). For unknown reasons, CZS incidence was highest in northeastern Brazil; one potential explanation is that dengue virus (DENV)–mediated immune enhancement may promote CZS development. In contrast, our analyses of historical DENV genomic data refuted the hypothesis that unique genome signatures for northeastern Brazil explain the uneven dispersion of CZS cases. To confirm our findings, we performed serotype-specific DENV neutralization tests in a case–control framework in northeastern Brazil among 29 Zika virus–seropositive mothers of neonates with CZS and 108 Zika virus–seropositive control mothers. Neutralization titers did not differ significantly between groups. In contrast, DENV seroprevalence and median number of neutralized serotypes were significantly lower among the mothers of neonates with CZS. Supported by model analyses, our results suggest that multitypic DENV