Possibilities of using a Frax® risk calculator for 10-year probability of fractures assessment in patients with rheumatoid arthritis [Возможности...
Никитинскайа О. А., Торопцова Н. В., Насонов Е. Л.
Научно-практическая ревматология
Т. 57, Вып. 3, С. 284-288
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.14412/1995-4484-2019-284-288
Аннотация:
Rheumatoid arthritis (RA) and glucocorticoid use are the most common causes of secondary osteoporosis (OP). Early detection of individuals at high risk for osteoporotic fractures among RA patients allows timely prevention of OP and its complications. Objective: to evaluate the diagnostic possibilities of using a FRAX® calculator without introducing femoral neck bone mineral density (BMD) into the algorithm, as well as different therapeutic intervention thresholds to identify RA patients who need anti-osteoporotic therapy. Subjects and methods. The investigation enrolled 97 RA patients aged over 50 years. A questionnaire survey and axial skeletal densitometry were made; the 10-year fracture risk was calculated using the FRAX® calculator with and without femoral neck BMD. The diagnostic characteristics (sensitivity, specificity, ROC-curves) of different therapeutic intervention thresholds (Russian and European age-dependent intervention thresholds; 20[%] and 10[%]) for FRAX) were studied. Re
Ключевые слова:
10-year fracture risk; Bone mineral density; FRAX®; Osteoporosis; Rheumatoid arthritis; Therapeutic intervention threshold
adult; Article; bone density; densitometry; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; dual energy X ray absorptiometry; femoral neck; fracture; frax calculator; human; lumbar spine; major clinical study; questionnaire; receiver operating characteristic; rheumatoid arthritis; risk assessment; sensitivity and specificity
Язык текста: Русский
ISSN: 1995-4492
Никитинскайа О. А.
Торопцова Н. В.
Насонов Е. Л. Евгений Львович 1948-
Nikitinskaya O. A.
Toroptsova N. V.
Nasonov E. L. Evgenij L`vovich 1948-
Possibilities of using a Frax® risk calculator for 10-year probability of fractures assessment in patients with rheumatoid arthritis [Возможности использования калькулятора 10-летней вероятности переломов FRAX® у больных ревматоидным артритом]
Possibilities of using a Frax® risk calculator for 10-year probability of fractures assessment in patients with rheumatoid arthritis [Возможности...
Текст визуальный непосредственный
Научно-практическая ревматология
ИМА-Пресс
Т. 57, Вып. 3 С. 284-288
2019
Статья
10-year fracture risk Bone mineral density FRAX® Osteoporosis Rheumatoid arthritis Therapeutic intervention threshold
adult Article bone density densitometry diagnostic accuracy diagnostic test accuracy study diagnostic value dual energy X ray absorptiometry femoral neck fracture frax calculator human lumbar spine major clinical study questionnaire receiver operating characteristic rheumatoid arthritis risk assessment sensitivity and specificity
Rheumatoid arthritis (RA) and glucocorticoid use are the most common causes of secondary osteoporosis (OP). Early detection of individuals at high risk for osteoporotic fractures among RA patients allows timely prevention of OP and its complications. Objective: to evaluate the diagnostic possibilities of using a FRAX® calculator without introducing femoral neck bone mineral density (BMD) into the algorithm, as well as different therapeutic intervention thresholds to identify RA patients who need anti-osteoporotic therapy. Subjects and methods. The investigation enrolled 97 RA patients aged over 50 years. A questionnaire survey and axial skeletal densitometry were made; the 10-year fracture risk was calculated using the FRAX® calculator with and without femoral neck BMD. The diagnostic characteristics (sensitivity, specificity, ROC-curves) of different therapeutic intervention thresholds (Russian and European age-dependent intervention thresholds; 20[%] and 10[%]) for FRAX) were studied. Re