Insulin resistance in rheumatoid arthritis: Relationship to lipid metabolism disorders and metabolic syndrome [Инсулинорезистентность при...
Кондратьева Л. В., Попкова Т. В., Насонов Е. Л.
Научно-практическая ревматология
Т. 57, Вып. 3, С. 280-283
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.14412/1995-4484-2019-280-283
Аннотация:
Objective: to determine the incidence of insulin resistance (IR) in patients with rheumatoid arthritis (RA) and to assess the relationship of IR to blood lipid profile changes and the presence of metabolic syndrome (MS). Subjects and methods. The investigation enrolled 47 RA patients (41 women and 6 men) without a history of diabetes mellitus (DM) and with normal fasting glucose levels during examination. The patients' median age was 56 [39; 62] years; disease duration - 6 [5; 14] years. Most of the patients had low (40.4[%]) or moderate (42.6[%]) RA activity (DAS28). IR was diagnosed using the Homeostastic Model Assessment of Insulin Resistance (HOMA-IR) index 2.77. The presence of MS was assessed by the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATPIII) criteria and the International Diabetes Federation (IDF) criteria. Results and discussion. The median HOMA-IR value in RA patients was 1.7 [1.1; 3.2]. The HOMA-IR index correlated with age (r=0.3; p=0.04), body
Ключевые слова:
Abdominal obesity; Insulin resistance; Lipid profile; Metabolic syndrome; Rheumatoid arthritis
cholesterol; glucose; triacylglycerol; abdominal obesity; adult; age; Article; atherogenesis; body mass; cholesterol blood level; clinical article; DAS28; disease association; disease duration; disorders of lipid and lipoprotein metabolism; female; glucose blood level; heart infarction; heart muscle revascularization; homeostasis model assessment; human; hypertension; hypertriglyceridemia; incidence; insulin resistance; lipid fingerprinting; male; metabolic syndrome X; rheumatoid arthritis; triacylglycerol blood level; waist circumference
Язык текста: Русский
ISSN: 1995-4492
Кондратьева Л. В.
Попкова Т. В.
Насонов Е. Л. Евгений Льв��вич 1948-
Kondratyeva L. V.
Popkova T. V.
Nasonov E. L. Evgenij L`v��vich 1948-
Insulin resistance in rheumatoid arthritis: Relationship to lipid metabolism disorders and metabolic syndrome [Инсулинорезистентность при ревматоидном артрите: взаимосвязь с нарушениями липидного обмена и метаболическим синдромом]
Insulin resistance in rheumatoid arthritis: Relationship to lipid metabolism disorders and metabolic syndrome [Инсулинорезистентность при...
Текст визуальный непосредственный
Научно-практическая ревматология
ИМА-Пресс
Т. 57, Вып. 3 С. 280-283
2019
Статья
Abdominal obesity Insulin resistance Lipid profile Metabolic syndrome Rheumatoid arthritis
cholesterol glucose triacylglycerol abdominal obesity adult age Article atherogenesis body mass cholesterol blood level clinical article DAS28 disease association disease duration disorders of lipid and lipoprotein metabolism female glucose blood level heart infarction heart muscle revascularization homeostasis model assessment human hypertension hypertriglyceridemia incidence insulin resistance lipid fingerprinting male metabolic syndrome X rheumatoid arthritis triacylglycerol blood level waist circumference
Objective: to determine the incidence of insulin resistance (IR) in patients with rheumatoid arthritis (RA) and to assess the relationship of IR to blood lipid profile changes and the presence of metabolic syndrome (MS). Subjects and methods. The investigation enrolled 47 RA patients (41 women and 6 men) without a history of diabetes mellitus (DM) and with normal fasting glucose levels during examination. The patients' median age was 56 [39; 62] years; disease duration - 6 [5; 14] years. Most of the patients had low (40.4[%]) or moderate (42.6[%]) RA activity (DAS28). IR was diagnosed using the Homeostastic Model Assessment of Insulin Resistance (HOMA-IR) index 2.77. The presence of MS was assessed by the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATPIII) criteria and the International Diabetes Federation (IDF) criteria. Results and discussion. The median HOMA-IR value in RA patients was 1.7 [1.1; 3.2]. The HOMA-IR index correlated with age (r=0.3; p=0.04), body