The relationship between the efficacy of methotrexate in rheumatoid arthritis and the achieved level of its polyglutamates in erythrocytes (pilot...
Гриднева Г. И., Ю М. В., Демидова Н. В., Аронова Е. С., Пиванова А. В., Борисова М. А., Глухова С. И., Старкова А. С., Савушкина Н. М., Красненко С. О., Нурбаева К. С., Баимеева Н. В., Тюрин И. А., Лила А. М.
Научно-практическая ревматология
Т. 57, Вып. 2, С. 171-174
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.14412/1995-4484-2019-171-174
Аннотация:
Therapeutic control of the methotrexate (MT) polyglutamates (MTPG) level in erythrocytes can be an objective marker of the effective dose of MT prescribed for rheumatoid arthritis (RA). Objective: to assess the relationship between the level of MTPG in red blood cells and efficacy of the MT dose used by RA patients. Subjects and methods. The study included 60 patients with RA (44 women and 16 men over 18 years) who met the criteria of the American College of Rheumatology and the European League Against Rheumatism (ACR/EULAR) 2010 and received MT ≥20 mg/week subcutaneously for ≥12 weeks. The patients were divided into two groups of comparable age, sex, alcohol intake, number of smokers, body mass index (BMI), depending on the presence (group 1; n=30) or absence (group 2; n=30) of the effect of MT, according to the EULAR efficacy criteria (DAS28). The concentration of MTPG (total MTPG and metabolites of MTPG1 2, 3, 4, 5) was determined in erythrocytes by high-performance liquid chromatog
Ключевые слова:
Methotrexate; Polyglutamates; Rheumatoid arthritis; Therapeutic control
methotrexate; polyglutamic acid; adult; alcohol consumption; Article; body mass; clinical assessment; controlled study; erythrocyte; female; high performance liquid chromatography; human; human cell; major clinical study; male; mass spectrometry; rheumatoid arthritis; smoking
Язык текста: Русский
ISSN: 1995-4492
Гриднева Г. И.
М. В.
Демидова Н. В.
Аронова Е. С.
Пиванова А. В.
Борисова М. А.
Глухова С. И.
Старкова А. С.
Савушкина Н. М.
Красненко С. О.
Нурбаева К. С. Камила Сериковна 1995-
Баимеева Н. В.
Тюрин И. А.
Лила А. М.
Gridneva G. I.
Yu M. V.
Demidova N. V.
Aronova E. S.
Pivanova A. V.
Borisova M. A.
Glukhova S. I.
Starkova A. S.
Savushkina N. M.
Krasnenko S. O.
Nurbaeva K. S. Kamila Serikovna 1995-
Baimeeva N. V.
Tyurin I. A.
Lila A. M.
The relationship between the efficacy of methotrexate in rheumatoid arthritis and the achieved level of its polyglutamates in erythrocytes (pilot study) [Взаимосвязь между эффективностью метотрексата при ревматоидном артрите и достигнутым уровнем его полиглутаматов в эритроцитах (пилотное исследование)]
The relationship between the efficacy of methotrexate in rheumatoid arthritis and the achieved level of its polyglutamates in erythrocytes (pilot...
Текст визуальный непосредственный
Научно-практическая ревматология
ИМА-Пресс
Т. 57, Вып. 2 С. 171-174
2019
Статья
Methotrexate Polyglutamates Rheumatoid arthritis Therapeutic control
methotrexate polyglutamic acid adult alcohol consumption Article body mass clinical assessment controlled study erythrocyte female high performance liquid chromatography human human cell major clinical study male mass spectrometry rheumatoid arthritis smoking
Therapeutic control of the methotrexate (MT) polyglutamates (MTPG) level in erythrocytes can be an objective marker of the effective dose of MT prescribed for rheumatoid arthritis (RA). Objective: to assess the relationship between the level of MTPG in red blood cells and efficacy of the MT dose used by RA patients. Subjects and methods. The study included 60 patients with RA (44 women and 16 men over 18 years) who met the criteria of the American College of Rheumatology and the European League Against Rheumatism (ACR/EULAR) 2010 and received MT ≥20 mg/week subcutaneously for ≥12 weeks. The patients were divided into two groups of comparable age, sex, alcohol intake, number of smokers, body mass index (BMI), depending on the presence (group 1; n=30) or absence (group 2; n=30) of the effect of MT, according to the EULAR efficacy criteria (DAS28). The concentration of MTPG (total MTPG and metabolites of MTPG1 2, 3, 4, 5) was determined in erythrocytes by high-performance liquid chromatog