Аннотация:
Pulmonary hypertension (PH) is a clinical syndrome characterized by a progressive increase in pulmonary vascular resistance (PVR), which leads to remodeling of the right ventricle (RV), right heart failure and premature death of patients. Early diagnosis and monitoring of disease progression are crucial for making decisions about the necessary therapy. The gold standard for the diagnosis of pulmonary hypertension is the right heart catheterization. The estimation of systolic pressure in pulmonary artery by means of transthoracic echocardiography is also used for monitoring the course of the disease. At present, there is still a need for non-invasive biomarkers that reflect pathological changes in pulmonary arterial vessels and allow diagnosing of PH. Our review outlines the new data about some biomarkers potentially useful for diagnosis and prognostication of PH. These biomarkers (mid-regional pro-adrenomedullin, carboxyterminal pro-endothelin-1, copeptin, asymmetric dimethylarginine,
Ключевые слова:
Biomarkers; Diagnostic value; Prognostic value; Pulmonary arterial hypertension; Pulmonary hypertension
biological marker; echocardiography; heart catheterization; heart right ventricle function; heart ventricle; human; pulmonary artery; pulmonary hypertension; Biomarkers; Cardiac Catheterization; Echocardiography; Heart Ventricles; Humans; Hypertension, Pulmonary; Pulmonary Artery; Ventricular Dysfunction, Right
Гайнитдинова В. В. Вилия Вилевна 1975-
Авдеев С. Н. Сергей Николаевич 1968-
Gaynitdinova V. V. Viliya Vilevna 1975-
Avdeev S. N. Sergej Nikolaevich 1968-
Novel biomarkers of pulmonary hypertension [Новые биомаркеры легочной гипертензии]
Текст визуальный непосредственный
Кардиология
Общество специалистов по сердечной недостаточности
Т. 59, Вып. 7 С. 84-94
2019
Статья
Biomarkers Diagnostic value Prognostic value Pulmonary arterial hypertension Pulmonary hypertension
biological marker echocardiography heart catheterization heart right ventricle function heart ventricle human pulmonary artery pulmonary hypertension Biomarkers Cardiac Catheterization Echocardiography Heart Ventricles Humans Hypertension, Pulmonary Pulmonary Artery Ventricular Dysfunction, Right
Pulmonary hypertension (PH) is a clinical syndrome characterized by a progressive increase in pulmonary vascular resistance (PVR), which leads to remodeling of the right ventricle (RV), right heart failure and premature death of patients. Early diagnosis and monitoring of disease progression are crucial for making decisions about the necessary therapy. The gold standard for the diagnosis of pulmonary hypertension is the right heart catheterization. The estimation of systolic pressure in pulmonary artery by means of transthoracic echocardiography is also used for monitoring the course of the disease. At present, there is still a need for non-invasive biomarkers that reflect pathological changes in pulmonary arterial vessels and allow diagnosing of PH. Our review outlines the new data about some biomarkers potentially useful for diagnosis and prognostication of PH. These biomarkers (mid-regional pro-adrenomedullin, carboxyterminal pro-endothelin-1, copeptin, asymmetric dimethylarginine,