Interleukin 6 as a pathogenic factor mediating clinical manifestations and a therapeutic target for rheumatic diseases and depressive disorders...
Лисицyна Т. А., Велтишчев Д. Y., Лила А. М., Насонов Е. Л.
Научно-практическая ревматология
Т. 57, Вып. 3, С. 318-327
Опубликовано: 2019
Тип ресурса: Обзор
DOI:10.14412/1995-4484-2019-318-327
Аннотация:
The review summarizes current idea on the key role of interleukin 6 (IL-6) in the pathogenesis of rheumatic diseases (RDs) and depressive disorders. It considers in detail the mechanisms by which IL6 induces the clinical and laboratory manifestations of RDs and depression; the influence of precipitating and predisposing stress factors, including childhood mental traumas, which increase the risk of RDs and depression, on IL-6 production. Particular attention is paid to the consideration of prospects for using IL-6 inhibitors in the therapy of depression. © 2019 Ima-Press Publishing House. All rights reserved.
Ключевые слова:
Antidepressants; Depression; Inflammation; Interleukin 6; Interleukin 6 inhibitors; Mental disorders; Rheumatic diseases; Rheumatoid arthritis
interleukin 6; childhood trauma; clinical feature; depression; human; pathogenesis; psychotrauma; Review; rheumatic disease
Язык текста: Русский
ISSN: 1995-4492
Лисицyна Т. А.
Велтишчев Д. Y. Д.Ю.
Лила А. М.
Насонов Е. Л. Евгений Львович 1948-
Lisitsyna T. A.
Veltishchev D. Y. D.Yu.
Lila A. M.
Nasonov E. L. Evgenij L`vovich 1948-
Interleukin 6 as a pathogenic factor mediating clinical manifestations and a therapeutic target for rheumatic diseases and depressive disorders [Интерлейкин 6 как патогенетический фактор, опосредующий формирование клинических проявлений, и мишень для терапии ревматических заболеваний и депрессивных расстройств]
Interleukin 6 as a pathogenic factor mediating clinical manifestations and a therapeutic target for rheumatic diseases and depressive disorders...
Текст визуальный непосредственный
Научно-практическая ревматология
ИМА-Пресс
Т. 57, Вып. 3 С. 318-327
2019
Обзор
Antidepressants Depression Inflammation Interleukin 6 Interleukin 6 inhibitors Mental disorders Rheumatic diseases Rheumatoid arthritis
interleukin 6 childhood trauma clinical feature depression human pathogenesis psychotrauma Review rheumatic disease
The review summarizes current idea on the key role of interleukin 6 (IL-6) in the pathogenesis of rheumatic diseases (RDs) and depressive disorders. It considers in detail the mechanisms by which IL6 induces the clinical and laboratory manifestations of RDs and depression; the influence of precipitating and predisposing stress factors, including childhood mental traumas, which increase the risk of RDs and depression, on IL-6 production. Particular attention is paid to the consideration of prospects for using IL-6 inhibitors in the therapy of depression. © 2019 Ima-Press Publishing House. All rights reserved.