Аннотация:
Mebeverine is a musculotropic antispasmodic drug that is widely used in the treatment of irritable bowel syndrome. As an ester of mebeverine alcohol and veratric acid, mebeverin is quickly metabolized and is practically undetectable in blood plasma. The main goal of this work was establishing the structure of the main metabolites of mebeverin in human blood plasma. The study was conducted by time-of-flight mass spectrometry (LC-IT-TOF MS), metabolites of mebeverine were extracted from plasma with acetonitrile. When comparing chromatograms of blood plasma obtained before and after drug administration, four main peaks of metabolites were detected. To establish the structure of the compounds, mass spectra of the first and second order were taken. The first-order spectra were used to calculate the metabolite formula and the structure was determined from the fragmentation spectra, as well as by comparing the fragmentation spectra of mebeverine and its proposed metabolites. The proposed comp
Moskaleva N. E. Natal`ya Evgenyevna 1971-
Kuznetsov R. M. Roman Mikhaylovich 1977-
Markin P. A. Pavel Aleksandrovich 1996-
Appolonova S. A. Svetlana Aleksandrovna 1973-
Москалева Н. Е. Наталья Евгеньевна 1971-
Кузнецов Р. М. Роман Михайлович 1977-
Маркин П. А. Павел Александрович 1996-
Апполонова С. А. Светлана Александровна 1973-
Mass spectrometric characterization of plasma mebeverine metabolites and its synthesis
Текст визуальный непосредственный
Periodico Tche Quimica
Vol.16, Issue32 P. 633-646
2019
Статья
Mebeverine Metabolism Synthesis UHPLC-IT-TOF
Mebeverine is a musculotropic antispasmodic drug that is widely used in the treatment of irritable bowel syndrome. As an ester of mebeverine alcohol and veratric acid, mebeverin is quickly metabolized and is practically undetectable in blood plasma. The main goal of this work was establishing the structure of the main metabolites of mebeverin in human blood plasma. The study was conducted by time-of-flight mass spectrometry (LC-IT-TOF MS), metabolites of mebeverine were extracted from plasma with acetonitrile. When comparing chromatograms of blood plasma obtained before and after drug administration, four main peaks of metabolites were detected. To establish the structure of the compounds, mass spectra of the first and second order were taken. The first-order spectra were used to calculate the metabolite formula and the structure was determined from the fragmentation spectra, as well as by comparing the fragmentation spectra of mebeverine and its proposed metabolites. The proposed comp