Preoperative predictive model and nomogram for disease recurrence following radical nephroureterectomy for high grade upper tract urothelial carcinoma
Freifeld Y., Ghandour R., Singla N., Woldu S., Clinton T., Kulangara R., Bagrodia A., Matin S. F., Petros F. G., Raman J. D., Robyak H., Yan J., Zhu H., Rapoport L. M., Lotan Y., Margulis V.
Urologic Oncology
Vol.37, Issue10, P. 758-764
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.urolonc.2019.06.009
Аннотация:
Purpose: To identify preoperative risk factors for disease recurrence, following radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), and to create a predictive nomogram. Materials and methods: Based on a multicenter database, we identified patients who underwent RNU due to high grade UTUC. Urothelial carcinoma of the bladder or contralateral UTUC was not considered as recurrence. Cox regression model was used to determine the effect of different preoperative variables as predictors of recurrence. Results: Two hundred and forty-five patients were included in the analysis. The 2 and 5 years recurrence rates were 16.3[%] and 19.2[%], respectively. Factors associated with recurrence on univariable analysis were sessile architecture hazard ratio (HR) 3.16 (95[%] CI, 1.38–7.26, P = 0.006), ≥cT3 disease HR 2.30 (95[%] CI, 1.12–4.72, P= 0.023), age >65 HR 2.02 (95[%] CI, 1.00–4.05, P= 0.048), Eastern Cooperative Group > 0 HR 1.98 (95[%] CI, 1.09–3.57, P= 0.023), hydronephrosis HR
Ключевые слова:
Metastasis; Nephroureterectomy; Nomogram; Recurrence; Upper tract urothelial carcinoma; UTUC
hemoglobin; aged; Article; cancer patient; cancer recurrence; controlled study; estimated glomerular filtration rate; female; hemoglobin blood level; human; hydronephrosis; major clinical study; male; nephroureterectomy; nomogram; preoperative evaluation; priority journal; radical resection; retrospective study; transitional cell carcinoma; cancer grading; clinical trial; multicenter study; nephroureterectomy; nomogram; pathology; preoperative period; procedures; risk factor; transitional cell carcinoma; urinary tract tumor; Aged; Carcinoma, Transitional Cell; Female; Humans; Male; Neoplasm Grading; Nephroureterectomy; Nomograms; Preoperative Period; Retrospective Studies; Risk Factors; Urologic Neoplasms
Язык текста: Английский
ISSN: 1873-2496
Freifeld Y.
Ghandour R.
Singla N.
Woldu S.
Clinton T.
Kulangara R.
Bagrodia A.
Matin S. F.
Petros F. G.
Raman J. D.
Robyak H.
Yan J.
Zhu H.
Rapoport L. M. Leonid Moiseevich 1956-
Lotan Y.
Margulis V. Vitalij 1975-
Фреифелд Y.
Гхандоур Р.
Сингла Н.
Wолду С.
Cлинтон Т.
Кулангара Р.
Багродиа А.
Матин С. Ф.
Петрос Ф. Г.
Раман Й. Д.
Робяк Х.
Ян Й.
Жу Х.
Рапопорт Л. М. Леонид Моисеевич 1956-
Лотан Y.
Маргулис В. Виталий 1975-
Preoperative predictive model and nomogram for disease recurrence following radical nephroureterectomy for high grade upper tract urothelial carcinoma
Текст визуальный непосредственный
Urologic Oncology
Elsevier Science Publisher B.V.
Vol.37, Issue10 P. 758-764
2019
Статья
Metastasis Nephroureterectomy Nomogram Recurrence Upper tract urothelial carcinoma UTUC
hemoglobin aged Article cancer patient cancer recurrence controlled study estimated glomerular filtration rate female hemoglobin blood level human hydronephrosis major clinical study male nephroureterectomy nomogram preoperative evaluation priority journal radical resection retrospective study transitional cell carcinoma cancer grading clinical trial multicenter study nephroureterectomy nomogram pathology preoperative period procedures risk factor transitional cell carcinoma urinary tract tumor Aged Carcinoma, Transitional Cell Female Humans Male Neoplasm Grading Nephroureterectomy Nomograms Preoperative Period Retrospective Studies Risk Factors Urologic Neoplasms
Purpose: To identify preoperative risk factors for disease recurrence, following radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), and to create a predictive nomogram. Materials and methods: Based on a multicenter database, we identified patients who underwent RNU due to high grade UTUC. Urothelial carcinoma of the bladder or contralateral UTUC was not considered as recurrence. Cox regression model was used to determine the effect of different preoperative variables as predictors of recurrence. Results: Two hundred and forty-five patients were included in the analysis. The 2 and 5 years recurrence rates were 16.3[%] and 19.2[%], respectively. Factors associated with recurrence on univariable analysis were sessile architecture hazard ratio (HR) 3.16 (95[%] CI, 1.38–7.26, P = 0.006), ≥cT3 disease HR 2.30 (95[%] CI, 1.12–4.72, P= 0.023), age >65 HR 2.02 (95[%] CI, 1.00–4.05, P= 0.048), Eastern Cooperative Group > 0 HR 1.98 (95[%] CI, 1.09–3.57, P= 0.023), hydronephrosis HR