Human Lung Microbiome on the Way to Cancer
Kovaleva O. V., Romashin D., Zborovskaya I. B., Davy'dov M. M., Shogenov M. S., Gratchev A.
Journal of Immunology Research
Vol.2019, P. 1394191
Опубликовано: 2019
Тип ресурса: Обзор
Аннотация:
Recent research on cancer-associated microbial communities led to the accumulation of data on the interplay between bacteria, immune and tumor cells, the pathways of bacterial induction of carcinogenesis, and its meaningfulness for medicine. Microbial communities that have any kind of impact on tumor progression and microorganisms associated with tumors have been defined as oncobiome. Over the last decades, a number of studies were dedicated to Helicobacter pylori and its role in the progression of stomach tumors, so this correlation can be regarded as proven. Involvement of bacteria in the induction of lung cancer has been largely ignored for a long time, though some correlations between this type of cancer and lung microbiome were established. Despite the fact that in the present the microbial impact on lung cancer progression has many confirmations, the underlying mechanisms are poorly understood. Microorganisms can contribute to tumor initiation and progression through production o
Ключевые слова:
carcinogenesis; cell transformation; disease exacerbation; Helicobacter infection; Helicobacter pylori; human; immunology; intestine flora; lung; lung tumor; metabolism; microbiology; microflora; pathology; stomach tumor; Carcinogenesis; Cell Transformation, Neoplastic; Disease Progression; Gastrointestinal Microbiome; Helicobacter Infections; Helicobacter pylori; Humans; Lung; Lung Neoplasms; Microbiota; Stomach Neoplasms
Язык текста: Английский
ISSN: 2314-7156
Kovaleva O. V.
Romashin D.
Zborovskaya I. B.
Davy'dov M. M. Mikhail Mikhaylovich 1985-
Shogenov M. S.
Gratchev A.
Ковалева О. В.
Ромашин Д.
Зборовскайа И. Б.
Давыдов М. М. Михаил Михайлович 1985-
Шогенов М. С.
Гратчев А.
Human Lung Microbiome on the Way to Cancer
Текст визуальный непосредственный
Journal of Immunology Research
Hindawi Publishing Corporation
Vol.2019 P. 1394191
2019
Обзор
carcinogenesis cell transformation disease exacerbation Helicobacter infection Helicobacter pylori human immunology intestine flora lung lung tumor metabolism microbiology microflora pathology stomach tumor Carcinogenesis Cell Transformation, Neoplastic Disease Progression Gastrointestinal Microbiome Helicobacter Infections Helicobacter pylori Humans Lung Lung Neoplasms Microbiota Stomach Neoplasms
Recent research on cancer-associated microbial communities led to the accumulation of data on the interplay between bacteria, immune and tumor cells, the pathways of bacterial induction of carcinogenesis, and its meaningfulness for medicine. Microbial communities that have any kind of impact on tumor progression and microorganisms associated with tumors have been defined as oncobiome. Over the last decades, a number of studies were dedicated to Helicobacter pylori and its role in the progression of stomach tumors, so this correlation can be regarded as proven. Involvement of bacteria in the induction of lung cancer has been largely ignored for a long time, though some correlations between this type of cancer and lung microbiome were established. Despite the fact that in the present the microbial impact on lung cancer progression has many confirmations, the underlying mechanisms are poorly understood. Microorganisms can contribute to tumor initiation and progression through production o