Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases
Moldogazieva N. T., Mokhosoev I. M., Mel`nikova T. I., Porozov Yu. B., Terentiev A. A.
Oxidative Medicine and Cellular Longevity
Vol.2019, P. 3085756
Опубликовано: 2019
Тип ресурса: Обзор
Аннотация:
Oxidative stress is a consequence of the use of oxygen in aerobic respiration by living organisms and is denoted as a persistent condition of an imbalance between the generation of reactive oxygen species (ROS) and the ability of the endogenous antioxidant system (AOS) to detoxify them. The oxidative stress theory has been confirmed in many animal studies, which demonstrated that the maintenance of cellular homeostasis and biomolecular stability and integrity is crucial for cellular longevity and successful aging. Mitochondrial dysfunction, impaired protein homeostasis (proteostasis) network, alteration in the activities of transcription factors such as Nrf2 and NF-κB, and disturbances in the protein quality control machinery that includes molecular chaperones, ubiquitin-proteasome system (UPS), and autophagy/lysosome pathway have been observed during aging and age-related chronic diseases. The accumulation of ROS under oxidative stress conditions results in the induction of lipid pero
Ключевые слова:
advanced glycation end product; aging; animal; diseases; female; genetics; human; lipid peroxidation; mouse; oxidative stress; Aging; Animals; Disease; Female; Glycation End Products, Advanced; Humans; Lipid Peroxidation; Mice; Oxidative Stress
Язык текста: Английский
ISSN: 1942-0994
Moldogazieva N. T. Nurbubu Tentievna 1959-
Mokhosoev I. M.
Mel`nikova T. I. Tat`yana Il`inichna 1958-
Porozov Yu. B. Yurij Borisovich 1970-
Terentiev A. A.
Молдогазиева Н. Т. Нурбубу Тентиевна 1959-
Мохосоев И. М.
Мельникова Т. И. Татьяна Ильинична 1958-
Порозов Ю. Б. Юрий Борисович 1970-
Терентиев А. А.
Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases
Текст визуальный непосредственный
Oxidative Medicine and Cellular Longevity
Vol.2019 P. 3085756
2019
Обзор
advanced glycation end product aging animal diseases female genetics human lipid peroxidation mouse oxidative stress Aging Animals Disease Female Glycation End Products, Advanced Humans Lipid Peroxidation Mice Oxidative Stress
Oxidative stress is a consequence of the use of oxygen in aerobic respiration by living organisms and is denoted as a persistent condition of an imbalance between the generation of reactive oxygen species (ROS) and the ability of the endogenous antioxidant system (AOS) to detoxify them. The oxidative stress theory has been confirmed in many animal studies, which demonstrated that the maintenance of cellular homeostasis and biomolecular stability and integrity is crucial for cellular longevity and successful aging. Mitochondrial dysfunction, impaired protein homeostasis (proteostasis) network, alteration in the activities of transcription factors such as Nrf2 and NF-κB, and disturbances in the protein quality control machinery that includes molecular chaperones, ubiquitin-proteasome system (UPS), and autophagy/lysosome pathway have been observed during aging and age-related chronic diseases. The accumulation of ROS under oxidative stress conditions results in the induction of lipid pero