A review on coordination properties of thiol-containing chelating agents towards mercury, cadmium, and lead
Bjørklund G., Crisponi G., Nurchi V. M., Cappai R., Djordjevic A. B., Oset Ya. U.
Molecules
Vol.24, Issue18, Num.3247
Опубликовано: 2019
Тип ресурса: Обзор
DOI:10.3390/molecules24183247
Аннотация:
The present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). Currently, very few commercially available pharmaceuticals can successfully reduce or prevent the toxicity of these metals. The metal chelator meso-2,3-dimercaptosuccinic acid (DMSA) is considerably less toxic than the classical agent British anti-Lewisite (BAL, 2,3-dimercaptopropanol) and is the recommended agent in poisonings with Pb and organic Hg. Its toxicity is also lower than that of DMPS (dimercaptopropane sulfonate), although DMPS is the recommended agent in acute poisonings with Hg salts. It is suggested that intracellular Cd deposits and cerebral deposits of inorganic Hg, to some extent, can be mobilized by a combination of antidotes, but clinical experience with such combinations are lacking. Alpha-lipoic acid (α-LA) has been suggested for toxic metal detoxification but is not considered a drug of choice in clinical pr
Ключевые слова:
BAL; DMPS; DMSA; Metal chelator; Metal ion
chelating agent; coordination compound; animal; cadmium poisoning; chemical structure; chemistry; heavy metal poisoning; human; lead poisoning; mercurialism; Animals; Cadmium Poisoning; Chelating Agents; Coordination Complexes; Heavy Metal Poisoning; Humans; Lead Poisoning; Mercury Poisoning; Molecular Structure
Язык текста: Английский
ISSN: 1420-3049
Bjørklund G.
Crisponi G.
Nurchi V. M.
Cappai R.
Djordjevic A. B.
Oset Ya. U. Yan Ulav 1943-
Бйøрклунд Г.
Cриспони Г.
Нурчи В. М.
Cаппаи Р.
Дйордйевиc А. Б.
Осет Я. У. Ян Улав 1943-
A review on coordination properties of thiol-containing chelating agents towards mercury, cadmium, and lead
Текст визуальный непосредственный
Molecules
Springer-Verlag GmbH
Vol.24, Issue18 Num.3247
2019
Обзор
BAL DMPS DMSA Metal chelator Metal ion
chelating agent coordination compound animal cadmium poisoning chemical structure chemistry heavy metal poisoning human lead poisoning mercurialism Animals Cadmium Poisoning Chelating Agents Coordination Complexes Heavy Metal Poisoning Humans Lead Poisoning Mercury Poisoning Molecular Structure
The present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). Currently, very few commercially available pharmaceuticals can successfully reduce or prevent the toxicity of these metals. The metal chelator meso-2,3-dimercaptosuccinic acid (DMSA) is considerably less toxic than the classical agent British anti-Lewisite (BAL, 2,3-dimercaptopropanol) and is the recommended agent in poisonings with Pb and organic Hg. Its toxicity is also lower than that of DMPS (dimercaptopropane sulfonate), although DMPS is the recommended agent in acute poisonings with Hg salts. It is suggested that intracellular Cd deposits and cerebral deposits of inorganic Hg, to some extent, can be mobilized by a combination of antidotes, but clinical experience with such combinations are lacking. Alpha-lipoic acid (α-LA) has been suggested for toxic metal detoxification but is not considered a drug of choice in clinical pr