Antioxidant effects of satureja hortensis L. attenuate the anxiogenic effect of cisplatin in rats
Kumburovic I., Selakovic D., Juric T., Jovicic N., Mihailovic V., Stankovic J. K., Sreckovic N., Kumburovic D., Yakovlevich V., Rosic G.
Oxidative Medicine and Cellular Longevity
Vol.2019, Num.8307196
Опубликовано: 2020
Тип ресурса: Статья
Аннотация:
Numerous adverse effects of cisplatin-based therapy are usually accompanied by enhanced oxidative damage and cell apoptosis in various tissues. Even neurotoxic manifestations of cisplatin administration, such as the anxiogenic effect, appear along with the increased oxidative stress and apoptotic indicators in certain brain regions. Thirty-five Wistar albino male rats were divided into seven groups: control, cisplatin (received a single dose of cisplatin: 7.5 mg/kg), three groups with oral administration of Satureja hortensis L. methanolic extract (SH) (low: 50 mg/kg, middle: 100 mg/kg, and high dose: 200 mg/kg) along with cisplatin application, a group with the extract in high dose alone, and a silymarin group (cisplatin and silymarin: 100 mg/kg), in order to evaluate the antioxidant effects of SH on cisplatin-induced increase in the anxiety level. After completing 10-day pretreatments, behavioral testing was performed in the open field and the elevated plus maze, followed by an inves
Ключевые слова:
Brain; Cell death; Flavonoids; Oxidative stress; Rats; Tissue; Anti-apoptotic effects; Antiapoptotic activities; Antioxidant effect; Antioxidant supplementation; Elevated plus maze; Estimated parameter; Methanolic extracts; Oral administration; Antioxidants; antioxidant; caspase 3; cisplatin; glutathione; plant extract; protein Bax; Satureja hortensis extract; silymarin; unclassified drug; antioxidant; cisplatin; animal tissue; antiapoptotic activity; antioxidant activity; apoptosis; Article; controlled study; exploratory behavior; gene expression; hippocampal tissue; lipid peroxidation; locomotion; male; nonhuman; number of rearings; oxidative stress; proapoptotic activity; rat; Satureja hortensis; supplementation; animal; chemistry; plant; savory; Wistar rat; Antioxidants; Bombax; Dosage; Flavonoids; Indicators; Management; Stresses; Tissue; Animals; Antioxidants; Cisplatin; Male; Plants; Rats; Rats, Wistar; Satureja
Язык текста: Английский
ISSN: 1942-0994
Kumburovic I.
Selakovic D.
Juric T.
Jovicic N.
Mihailovic V.
Stankovic J. K.
Sreckovic N.
Kumburovic D.
Yakovlevich V. Vladimir 1971-
Rosic G.
Кумбуровиc И.
Селаковиc Д.
Йуриc Т.
Йовиcиc Н.
Михаиловиc В.
Станковиc Й. К.
Среcковиc Н.
Кумбуровиc Д.
Яковлевич В. Владимир 1971-
Росиc Г.
Antioxidant effects of satureja hortensis L. attenuate the anxiogenic effect of cisplatin in rats
Текст визуальный непосредственный
Oxidative Medicine and Cellular Longevity
Vol.2019 Num.8307196
2020
Статья
Brain Cell death Flavonoids Oxidative stress Rats Tissue Anti-apoptotic effects Antiapoptotic activities Antioxidant effect Antioxidant supplementation Elevated plus maze Estimated parameter Methanolic extracts Oral administration Antioxidants antioxidant caspase 3 cisplatin glutathione plant extract protein Bax Satureja hortensis extract silymarin unclassified drug antioxidant cisplatin animal tissue antiapoptotic activity antioxidant activity apoptosis Article controlled study exploratory behavior gene expression hippocampal tissue lipid peroxidation locomotion male nonhuman number of rearings oxidative stress proapoptotic activity rat Satureja hortensis supplementation animal chemistry plant savory Wistar rat Antioxidants Bombax Dosage Flavonoids Indicators Management Stresses Tissue Animals Antioxidants Cisplatin Male Plants Rats Rats, Wistar Satureja
Numerous adverse effects of cisplatin-based therapy are usually accompanied by enhanced oxidative damage and cell apoptosis in various tissues. Even neurotoxic manifestations of cisplatin administration, such as the anxiogenic effect, appear along with the increased oxidative stress and apoptotic indicators in certain brain regions. Thirty-five Wistar albino male rats were divided into seven groups: control, cisplatin (received a single dose of cisplatin: 7.5 mg/kg), three groups with oral administration of Satureja hortensis L. methanolic extract (SH) (low: 50 mg/kg, middle: 100 mg/kg, and high dose: 200 mg/kg) along with cisplatin application, a group with the extract in high dose alone, and a silymarin group (cisplatin and silymarin: 100 mg/kg), in order to evaluate the antioxidant effects of SH on cisplatin-induced increase in the anxiety level. After completing 10-day pretreatments, behavioral testing was performed in the open field and the elevated plus maze, followed by an inves