Morphological and immunohistochemical characteristics of the molecular subtypes of urothelial carcinomas
Османов Ю. И. О., Гаибов З. А., Коган Е. А., Раденска-Лоповок С. Г., Тюрсунов К. З.
Архив патологии
Т. 81, Вып. 5, С. 35-44
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.17116/patol20198105135
Аннотация:
The molecular subtypes of urothelial carcinoma in each classification scheme have characteristic immunohistochemical features. At the same time, the results of conducted studies often demonstrate a discrepancy between the genomic profile of urothelial carcinoma and its immunophenotype, which complicates the immunohistochemical verification of the molecular subtypes of these tumors. Objective - to compare the morphological and immunophenotypic characteristics of the molecular subtypes of urothelial carcinoma. Material and methods. Surgical specimens from 196 patients diagnosed with urothelial carcinoma of the renal pelvis and bladder were investigated. Paraffin-embedded sections were immunohistochemically examined using the standard protocol. Antibodies against CK5/6, CK17, Rb1 (Dako), CK14, CK18, CK20, Cyclin D1, Cyclin E1, Cyclin A, Cyclin B, Chromogranin, E-Cadherin, P-Cadherin, p16, Uroplakin II, TUBB2B, Vimentin, ZEB-2 («Novocastra»), CD44, GATA-3, and Uroplakin III («Cell Marque»)
Ключевые слова:
Bladder; Immunoprofile; Molecular classification; Renal pelvis; Urothelial carcinoma
tumor marker; classification; human; immunohistochemistry; papillary carcinoma; pathology; urinary tract tumor; Biomarkers, Tumor; Carcinoma, Papillary; Humans; Immunohistochemistry; Urologic Neoplasms
Язык текста: Русский
ISSN: 2309-1266
Османов Ю. И. О. Юсиф Ислам Оглы 1975-
Гаибов З. А.
Коган Е. А. Евгения Алтаровна 1951-
Раденска-Лоповок С. Г. Стефка Господинова 1951-
Тюрсунов К. З.
Osmanov Yu. I. O. Yusif Islam Ogly' 1975-
Gaibov Z. A.
Kogan E. A. Evgeniya Altarovna 1951-
Radenska-Lopovok S. G. Stefka Gospodinova 1951-
Tursunov K. Z.
Morphological and immunohistochemical characteristics of the molecular subtypes of urothelial carcinomas
Текст визуальный непосредственный
Архив патологии
Издательство Медиа Сфера
Т. 81, Вып. 5 С. 35-44
2019
Статья
Bladder Immunoprofile Molecular classification Renal pelvis Urothelial carcinoma
tumor marker classification human immunohistochemistry papillary carcinoma pathology urinary tract tumor Biomarkers, Tumor Carcinoma, Papillary Humans Immunohistochemistry Urologic Neoplasms
The molecular subtypes of urothelial carcinoma in each classification scheme have characteristic immunohistochemical features. At the same time, the results of conducted studies often demonstrate a discrepancy between the genomic profile of urothelial carcinoma and its immunophenotype, which complicates the immunohistochemical verification of the molecular subtypes of these tumors. Objective - to compare the morphological and immunophenotypic characteristics of the molecular subtypes of urothelial carcinoma. Material and methods. Surgical specimens from 196 patients diagnosed with urothelial carcinoma of the renal pelvis and bladder were investigated. Paraffin-embedded sections were immunohistochemically examined using the standard protocol. Antibodies against CK5/6, CK17, Rb1 (Dako), CK14, CK18, CK20, Cyclin D1, Cyclin E1, Cyclin A, Cyclin B, Chromogranin, E-Cadherin, P-Cadherin, p16, Uroplakin II, TUBB2B, Vimentin, ZEB-2 («Novocastra»), CD44, GATA-3, and Uroplakin III («Cell Marque»)