The influence of succinate-containing drugs on the process of neuroplasticity after ischemic stroke
Екушева Е. В.
Экспериментальная и клиническая фармакология
Т. 81, Вып. 8, С. 37-44
Опубликовано: 2018
Тип ресурса: Обзор
DOI:10.30906/0869-2092-2018-81-8-37-44
Аннотация:
Succinate is an endogenous substrate of the human organism that participates in various redox processes, reactions of the Krebs cycle, and the mitochondrial oxidation chain. This universal intracellular metabolite plays an important role in the regulation of physiological, metabolic, and energy-producing processes. The article discusses the issues of neuroplasticity, the importance of correction of energy deficiency, oxidative stress and other pathophysiological processes, and maintenance of adequate functional activity of neuronal structures after cerebral circulation disorders. The problems of neuroprotective therapy in ischemic stroke, which is pathogenetically justified in all stages of restorative treatment after cerebrovascular accident, are considered. Cytoflavin is one of the most studied original cytoprotectors, which demonstrated safety, efficacy, and good tolerability. Results of numerous clinical trials revealed significant positive clinical and morphological dynamics of cy
Ключевые слова:
Cytoflavin; Ischemic stroke; Neuroplasticity; Succinate
cytoflavin; cytoprotective agent; neuroprotective agent; succinic acid derivative; unclassified drug; brain ischemia; drug efficacy; drug safety; drug tolerability; human; mitochondrial respiration; nerve cell plasticity; neuroprotection; oxidation reduction reaction; Review; stroke patient
Язык текста: Русский
ISSN: 0869-2092
Екушева Е. В.
Ekusheva E. V.
The influence of succinate-containing drugs on the process of neuroplasticity after ischemic stroke
Текст визуальный непосредственный
Экспериментальная и клиническая фармакология
ООО "Фолиум"
Т. 81, Вып. 8 С. 37-44
2018
Обзор
Cytoflavin Ischemic stroke Neuroplasticity Succinate
cytoflavin cytoprotective agent neuroprotective agent succinic acid derivative unclassified drug brain ischemia drug efficacy drug safety drug tolerability human mitochondrial respiration nerve cell plasticity neuroprotection oxidation reduction reaction Review stroke patient
Succinate is an endogenous substrate of the human organism that participates in various redox processes, reactions of the Krebs cycle, and the mitochondrial oxidation chain. This universal intracellular metabolite plays an important role in the regulation of physiological, metabolic, and energy-producing processes. The article discusses the issues of neuroplasticity, the importance of correction of energy deficiency, oxidative stress and other pathophysiological processes, and maintenance of adequate functional activity of neuronal structures after cerebral circulation disorders. The problems of neuroprotective therapy in ischemic stroke, which is pathogenetically justified in all stages of restorative treatment after cerebrovascular accident, are considered. Cytoflavin is one of the most studied original cytoprotectors, which demonstrated safety, efficacy, and good tolerability. Results of numerous clinical trials revealed significant positive clinical and morphological dynamics of cy