Elevated levels of serum nitrite and nitrate, NOx, are associated with increased total and cardiovascular mortality in an 8-year follow-up study
Gumanova N. G., Deev A. D., Kots A., Shalnova S. A.
European Journal of Clinical Investigation
Vol.49, Issue3, Num.e13061
Опубликовано: 2019
Тип ресурса: Статья
Аннотация:
Background: Nitric oxide (NO) is one of the key regulators of vascular function. Abnormal NO signalling is linked to various cardiovascular diseases. We studied associations between circulating levels of NO metabolites, nitrite and nitrate (NOx) and total and cardiovascular mortality in a prospective 8-year follow-up cohort study in 1869 patients aged over 55 years. Materials and methods: The Cox proportional hazard ratio (HR) regression models were adjusted for multiple risk-related variables. Post hoc Kaplan-Meier survival curves were compared by the Log-rank test. Results: Proportional Cox regression analysis demonstrated that high serum levels of NOx over 70 µmol/L were associated with elevated total mortality (HR 1.4; 95[%] CI: 1.06-1.80; P = 0.02) and cardiovascular mortality (HR 1.4; 95[%] CI: 0.98-1.98; P = 0.03) when HR was adjusted for age, sex, smoking and urinary creatinine. Additional adjustments for various mortality-associated baseline comorbidities did not influence associa
Ключевые слова:
cardiovascular mortality; nitrate; nitric oxide; nitrite; NOx; total mortality
cholesterol; creatinine; fibrinogen; high density lipoprotein cholesterol; interleukin 6; low density lipoprotein cholesterol; nitrate; nitric oxide; nitrite; triacylglycerol; nitric acid derivative; nitric oxide; nitrite; aged; Article; blood level; cardiovascular mortality; cholesterol blood level; cohort analysis; comorbidity; comparative study; controlled study; creatinine urine level; female; fibrinogen blood level; follow up; human; major clinical study; male; priority journal; randomized controlled trial; smoking; survival rate; triacylglycerol blood level; blood; cardiovascular disease; clinical trial; epidemiology; Kaplan Meier method; metabolism; middle aged; mortality; multicenter study; prospective study; risk factor; Russian Federation; Aged; Cardiovascular Diseases; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Moscow; Nitrates; Nitric Oxide; Nitrites; Prospective Studies; Risk Factors
Язык текста: Английский
ISSN: 1365-2362
Gumanova N. G.
Deev A. D.
Kots A. Aleksandr 1967-
Shalnova S. A.
Гуманова Н. Г.
Деев А. Д.
Коц А. Александр 1967-
Шалнова С. А.
Elevated levels of serum nitrite and nitrate, NOx, are associated with increased total and cardiovascular mortality in an 8-year follow-up study
Текст визуальный непосредственный
European Journal of Clinical Investigation
John Wiley & Sons, Inc.
Vol.49, Issue3 Num.e13061
2019
Статья
cardiovascular mortality nitrate nitric oxide nitrite NOx total mortality
cholesterol creatinine fibrinogen high density lipoprotein cholesterol interleukin 6 low density lipoprotein cholesterol nitrate nitric oxide nitrite triacylglycerol nitric acid derivative nitric oxide nitrite aged Article blood level cardiovascular mortality cholesterol blood level cohort analysis comorbidity comparative study controlled study creatinine urine level female fibrinogen blood level follow up human major clinical study male priority journal randomized controlled trial smoking survival rate triacylglycerol blood level blood cardiovascular disease clinical trial epidemiology Kaplan Meier method metabolism middle aged mortality multicenter study prospective study risk factor Russian Federation Aged Cardiovascular Diseases Female Follow-Up Studies Humans Kaplan-Meier Estimate Male Middle Aged Moscow Nitrates Nitric Oxide Nitrites Prospective Studies Risk Factors
Background: Nitric oxide (NO) is one of the key regulators of vascular function. Abnormal NO signalling is linked to various cardiovascular diseases. We studied associations between circulating levels of NO metabolites, nitrite and nitrate (NOx) and total and cardiovascular mortality in a prospective 8-year follow-up cohort study in 1869 patients aged over 55 years. Materials and methods: The Cox proportional hazard ratio (HR) regression models were adjusted for multiple risk-related variables. Post hoc Kaplan-Meier survival curves were compared by the Log-rank test. Results: Proportional Cox regression analysis demonstrated that high serum levels of NOx over 70 µmol/L were associated with elevated total mortality (HR 1.4; 95[%] CI: 1.06-1.80; P = 0.02) and cardiovascular mortality (HR 1.4; 95[%] CI: 0.98-1.98; P = 0.03) when HR was adjusted for age, sex, smoking and urinary creatinine. Additional adjustments for various mortality-associated baseline comorbidities did not influence associa