Tortuosity of the superficial femoral artery and its influence on blood flow patterns and risk of atherosclerosis
Li X., Liu X., Xu L., Chen X., Lyan F.
Biomechanics and Modeling in Mechanobiology
Vol.18, Issue4, P. 883-896
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1007/s10237-019-01118-4
Аннотация:
The superficial femoral artery (SFA) is a typical atherosclerosis-prone site. We aimed to explore whether the tortuosity of the SFA associates with the occurrence of atherosclerosis and investigate how vascular tortuosity influences the characteristics of blood flow. Ten patients diagnosed with atherosclerotic disease in their SFAs while free of systemic atherosclerosis risk factors were enrolled together with ten atherosclerosis-free patients. The tortuosity of each SFA was quantitatively evaluated by calculating the averaged curvature (AC), maximum curvature (MC) and fraction of high curvature (FC) based on the geometrical model reconstructed from medical images. Hemodynamic studies were performed using both geometrically simplified and anatomically realistic models of the SFA to systematically address the hemodynamic effects of vascular tortuosity. Morphological analyses revealed that all curvature indices of the SFA were significantly larger in patients with atherosclerosis than in
Ключевые слова:
Atherosclerosis; High oscillatory shear index; Low wall shear stress; Superficial femoral artery; Tortuosity
Blood; Hemodynamics; Medical imaging; Patient monitoring; Shear flow; Shear stress; Atherosclerosis; Oscillatory shear index; Superficial femoral arteries; Tortuosity; Wall shear stress; Diseases; adult; artery blood flow; Article; atherosclerosis; blood vessel parameters; cardiovascular risk; clinical article; controlled study; female; human; image reconstruction; male; middle aged; priority journal; simulation; superficial femoral artery; systemic disease; vascular tortuosity; aged; artery; atherosclerosis; biological model; circulation; congenital blood vessel malformation; femoral artery; hemodynamics; joint instability; pathophysiology; physiology; risk factor; skin disease; Adult; Aged; Arteries; Atherosclerosis; Blood Circulation; Female; Femoral Artery; Hemodynamics; Humans; Joint Instability; Male; Middle Aged; Models, Cardiovascular; Risk Factors; Skin Diseases, Genetic; Vascular Malformations
Язык текста: Английский
ISSN: 1617-7940
Li X.
Liu X.
Li X.
Xu L.
Chen X.
Lyan F. Fuyu 1978-
Ли Х.
Лиу Х.
Ли Х.
Ху Л.
Чен Х.
Лян Ф. Фую 1978-
Tortuosity of the superficial femoral artery and its influence on blood flow patterns and risk of atherosclerosis
Текст визуальный непосредственный
Biomechanics and Modeling in Mechanobiology
Springer-Verlag GmbH
Vol.18, Issue4 P. 883-896
2019
Статья
Atherosclerosis High oscillatory shear index Low wall shear stress Superficial femoral artery Tortuosity
Blood Hemodynamics Medical imaging Patient monitoring Shear flow Shear stress Atherosclerosis Oscillatory shear index Superficial femoral arteries Tortuosity Wall shear stress Diseases adult artery blood flow Article atherosclerosis blood vessel parameters cardiovascular risk clinical article controlled study female human image reconstruction male middle aged priority journal simulation superficial femoral artery systemic disease vascular tortuosity aged artery atherosclerosis biological model circulation congenital blood vessel malformation femoral artery hemodynamics joint instability pathophysiology physiology risk factor skin disease Adult Aged Arteries Atherosclerosis Blood Circulation Female Femoral Artery Hemodynamics Humans Joint Instability Male Middle Aged Models, Cardiovascular Risk Factors Skin Diseases, Genetic Vascular Malformations
The superficial femoral artery (SFA) is a typical atherosclerosis-prone site. We aimed to explore whether the tortuosity of the SFA associates with the occurrence of atherosclerosis and investigate how vascular tortuosity influences the characteristics of blood flow. Ten patients diagnosed with atherosclerotic disease in their SFAs while free of systemic atherosclerosis risk factors were enrolled together with ten atherosclerosis-free patients. The tortuosity of each SFA was quantitatively evaluated by calculating the averaged curvature (AC), maximum curvature (MC) and fraction of high curvature (FC) based on the geometrical model reconstructed from medical images. Hemodynamic studies were performed using both geometrically simplified and anatomically realistic models of the SFA to systematically address the hemodynamic effects of vascular tortuosity. Morphological analyses revealed that all curvature indices of the SFA were significantly larger in patients with atherosclerosis than in