Co-expression of membrane-bound TNF-alpha type 1 and 2 receptors differ in the subsets of immunocompetent cells
Sennikov S., Alshevskaya A., Zhukova J., Belomestnova I., Karaulov A. V., Evsegneeva I. V., Lopatnikova J.
Immunology Letters
Vol.207, P. 1-5
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.imlet.2019.01.005
Аннотация:
The immunoregulatory cytokine tumor necrosis factor α plays crucial roles in the pathogenesis of a broad spectrum of disorders. However, its effect may depend on the expression and co-expression of receptors on the target cell. The aim of the present study was to evaluate the expression levels of type 1 and 2 tumor necrosis factor α receptors (TNFR1/2) on individual cell subsets from peripheral blood of healthy volunteers. Flow cytometry analysis was used to study whole populations as well as subsets (T regulatory cells, T memory cells, cytotoxic T cells, T helper cells). Significant differences in the co-expression of TNFR1/2 were seen within subsets and total pools. Further studies are necessary to explore the implications of the observed differences in the modulation of tumor necrosis factor α function in health and pathology. © 2019 European Federation of Immunological Societies
Ключевые слова:
Cellular immunology; Cytokine receptors expression; Immune regulation
tumor necrosis factor receptor 1; tumor necrosis factor receptor 2; adult; aged; Article; controlled study; cytotoxic T lymphocyte; female; flow cytometry; helper cell; human; human cell; immunocompetent cell; immunoregulation; lymphocyte function; male; membrane binding; memory T lymphocyte; neuromodulation; normal value; priority journal; protein expression; receptor binding; regulatory T lymphocyte; T lymphocyte subpopulation
Язык текста: Английский
ISSN: 1879-0542
Sennikov S.
Alshevskaya A.
Zhukova J.
Belomestnova I.
Karaulov A. V. Aleksandr Viktorovich 1953-
Evsegneeva I. V. Irina Valentinovna 1967-
Lopatnikova J.
Сенников С.
Алшевскайа А.
Жукова Й.
Беломестнова И.
Караулов А. В. Александр Викторович 1953-
Евсегнеева И. В. Ирина Валентиновна 1967-
Лопатникова Й.
Co-expression of membrane-bound TNF-alpha type 1 and 2 receptors differ in the subsets of immunocompetent cells
Текст визуальный непосредственный
Immunology Letters
Elsevier Science Publisher B.V.
Vol.207 P. 1-5
2019
Статья
Cellular immunology Cytokine receptors expression Immune regulation
tumor necrosis factor receptor 1 tumor necrosis factor receptor 2 adult aged Article controlled study cytotoxic T lymphocyte female flow cytometry helper cell human human cell immunocompetent cell immunoregulation lymphocyte function male membrane binding memory T lymphocyte neuromodulation normal value priority journal protein expression receptor binding regulatory T lymphocyte T lymphocyte subpopulation
The immunoregulatory cytokine tumor necrosis factor α plays crucial roles in the pathogenesis of a broad spectrum of disorders. However, its effect may depend on the expression and co-expression of receptors on the target cell. The aim of the present study was to evaluate the expression levels of type 1 and 2 tumor necrosis factor α receptors (TNFR1/2) on individual cell subsets from peripheral blood of healthy volunteers. Flow cytometry analysis was used to study whole populations as well as subsets (T regulatory cells, T memory cells, cytotoxic T cells, T helper cells). Significant differences in the co-expression of TNFR1/2 were seen within subsets and total pools. Further studies are necessary to explore the implications of the observed differences in the modulation of tumor necrosis factor α function in health and pathology. © 2019 European Federation of Immunological Societies