Synthesis, characterization and biological evaluation of Zn(II) and Co(II) complexes of N-allylimidazole as potential hypoxia-targeting agents
Parshina L. N., Grishchenko L. A., Smirnov V. I., Borodina T. N., Lebedeva S. A., Tarasov V. V., Apartsin K. A., Kireeva V. V., Trofimov B. A.
Polyhedron
Vol.161, P. 126-131
Опубликовано: 2019
Тип ресурса: Статья
DOI:10.1016/j.poly.2019.01.005
Аннотация:
Zinc(II) and cobalt(II) complexes of N-allylimidazole, bis(N-allylimidazole)zinc diacetate (1) and bis(N-allylimidazole)cobalt dichloride (2), have been prepared and characterized by X-ray crystallography, NMR, FTIR spectroscopy, microanalysis and melting point. The single crystal X-ray diffraction analysis confirms that compounds 1 and 2 are monomeric with tetra-coordinate zinc and cobalt centers. Complexes 1 and 2 have been tested using four in vivo models of acute hypoxia of different genesis (hypobaric, hemic, histotoxic, hypoxia with hypercapnia). Complex 1 reveals a moderate effect against the hemic and histotoxic hypoxia, and a high effect against the hypobaric hypoxia and hypoxia with hypercapnia, while complex 2 demonstrates a high antihypoxic activity in all the studied models. © 2019 Elsevier Ltd
Ключевые слова:
Antihypoxic activity; Cobalt; N-allylimidazol complexes; X-ray diffraction; Zinc
Язык текста: Английский
ISSN: 0277-5387
Parshina L. N.
Grishchenko L. A.
Smirnov V. I.
Borodina T. N.
Lebedeva S. A. Svetlana Anatolyevna 1974-
Tarasov V. V. Vadim Vladimirovich 1987-
Apartsin K. A.
Kireeva V. V.
Trofimov B. A.
Паршина Л. Н.
Гришченко Л. А.
Смирнов В. И.
Бородина Т. Н.
Лебедева С. А. Светлана Анатольевна 1974-
Тарасов В. В. Вадим Владимирович 1987-
Апарцин К. А.
Киреева В. В.
Трофимов Б. А.
Synthesis, characterization and biological evaluation of Zn(II) and Co(II) complexes of N-allylimidazole as potential hypoxia-targeting agents
Текст визуальный непосредственный
Polyhedron
Elsevier Science Publisher B.V.
Vol.161 P. 126-131
2019
Статья
Antihypoxic activity Cobalt N-allylimidazol complexes X-ray diffraction Zinc
Zinc(II) and cobalt(II) complexes of N-allylimidazole, bis(N-allylimidazole)zinc diacetate (1) and bis(N-allylimidazole)cobalt dichloride (2), have been prepared and characterized by X-ray crystallography, NMR, FTIR spectroscopy, microanalysis and melting point. The single crystal X-ray diffraction analysis confirms that compounds 1 and 2 are monomeric with tetra-coordinate zinc and cobalt centers. Complexes 1 and 2 have been tested using four in vivo models of acute hypoxia of different genesis (hypobaric, hemic, histotoxic, hypoxia with hypercapnia). Complex 1 reveals a moderate effect against the hemic and histotoxic hypoxia, and a high effect against the hypobaric hypoxia and hypoxia with hypercapnia, while complex 2 demonstrates a high antihypoxic activity in all the studied models. © 2019 Elsevier Ltd