Аннотация:
This study focused on genetically determined versus acquired factors in shaping anxiety-related behavior by combining cross-breeding and cross-fostering approaches. Via cross-breeding of HAB (high anxietyrelated behavior) female and LAB (low anxiety-related behavior) male mice, we obtained F1 hybrids with intermediate anxiety levels carrying genetic characteristics of both parental lines. Pups were raised either by their biological HAB (noncross-fostered control) or foster LAB (cross-fostered) mothers. Compared to controls, 6-week-old offspring raised by LAB mothers showed lower levels of anxiety in the elevated plus-maze and open field, but not the light-dark box, tests. No differences were found in the forced swim test reflecting active versus passive coping. The behavioral changes were associated with increased stress-induced concentrations of plasma corticosterone in cross-fostered animals. The expression of the corticotropin-releasing hormone receptor type I and glucocorticoid rec
Ключевые слова:
anxiety; corticosterone; cross-fostering; maternal care; stress
corticosterone; corticotropin releasing factor receptor; glucocorticoid receptor; corticosterone; corticotropin releasing factor receptor; corticotropin releasing factor receptor 1; animal behavior; animal experiment; anxiety; Article; behavior change; body weight; breeding; controlled study; coping behavior; corticosterone blood level; cross breeding; elevated plus maze test; female; forced swim test; gene expression; genetic trait; heredity; hypothalamus; limbic cortex; male; maternal care; mouse; neuroendocrine system; nonhuman; open field test; progeny; animal; anxiety; blood; disease model; genetics; genotype environment interaction; metabolism; species difference; Animals; Anxiety; Behavior, Animal; Breeding; Corticosterone; Disease Models, Animal; Female; Gene-Environment Interaction; Male; Receptors, Corticotropin-Releasing Hormone; Species Specificity
Chekmareva N. Yu. Natal`ya Yuryevna 1989-
Umryukhin A. E. Aleksej Evgenyevich 1978-
Landgraf R. J. Rayner Jokhannes 1950-
Neizvestny'j 0001-
Чекмарева Н. Ю. Наталья Юрьевна 1989-
Умрюхин А. Е. Алексей Евгеньевич 1978-
Ландграф Р. Й. Райнер Йоханнес 1950-
Неизвестный 0001-
Inborn vs. acquired anxiety in cross-breeding and cross-fostering HAB/LAB mice bred for extremes in anxiety-related behavior
Текст визуальный непосредственный
Behavioral Neuroscience
American Psychological Association (PsycARTICLES)
Vol.133, Issue1 P. 68-76
2019
Статья
anxiety corticosterone cross-fostering maternal care stress
corticosterone corticotropin releasing factor receptor glucocorticoid receptor corticosterone corticotropin releasing factor receptor corticotropin releasing factor receptor 1 animal behavior animal experiment anxiety Article behavior change body weight breeding controlled study coping behavior corticosterone blood level cross breeding elevated plus maze test female forced swim test gene expression genetic trait heredity hypothalamus limbic cortex male maternal care mouse neuroendocrine system nonhuman open field test progeny animal anxiety blood disease model genetics genotype environment interaction metabolism species difference Animals Anxiety Behavior, Animal Breeding Corticosterone Disease Models, Animal Female Gene-Environment Interaction Male Receptors, Corticotropin-Releasing Hormone Species Specificity
This study focused on genetically determined versus acquired factors in shaping anxiety-related behavior by combining cross-breeding and cross-fostering approaches. Via cross-breeding of HAB (high anxietyrelated behavior) female and LAB (low anxiety-related behavior) male mice, we obtained F1 hybrids with intermediate anxiety levels carrying genetic characteristics of both parental lines. Pups were raised either by their biological HAB (noncross-fostered control) or foster LAB (cross-fostered) mothers. Compared to controls, 6-week-old offspring raised by LAB mothers showed lower levels of anxiety in the elevated plus-maze and open field, but not the light-dark box, tests. No differences were found in the forced swim test reflecting active versus passive coping. The behavioral changes were associated with increased stress-induced concentrations of plasma corticosterone in cross-fostered animals. The expression of the corticotropin-releasing hormone receptor type I and glucocorticoid rec