Аннотация:
The most common cause of male infertility is idiopathic oligo-, and or astheno-, and /or teratozoospermia. In such cases, anti-estrogens, antioxidants (vitamins and trace elements) or carnitines are used, but the evidence on their effectiveness is inconsistent; there are currently no published studies exploring their concurrent use.AIM: To investigate the efficacy and safety of the L- and acetyl-L-carnitine complex, vitamins A, E, C, selenium, zinc and other antioxidants ("SpermActin" + "More than vitamins") in combination with clomiphene citrate (CC) in managing male idiopathic infertility in the form of oligo, and/or astheno-, and/or teratozoospermia.MATERIALS AND METHODS: The study comprised 173 men from infertile couples aged 25-45 years who were divided into two groups - the study group (n=88) and control group (n=85). All the patients were examined according to the WHO recommendations. Patients of the study group received L-carnitine fumarate (1 g), acetyl-L-carnitine (0.5 g) twi
Ключевые слова:
anti-estrogens; anti-oxidants; carnitine; clomiphene citrate; male infertility
acetylcarnitine; antioxidant; clomifene; mineral; selenium; vitamin; zinc; adult; Asthenozoospermia; combination drug therapy; controlled study; drug effects; human; male; middle aged; oligospermia; randomized controlled trial; sperm; spermatozoon; spermatozoon motility; Teratozoospermia; Acetylcarnitine; Adult; Antioxidants; Asthenozoospermia; Clomiphene; Drug Therapy, Combination; Humans; Male; Middle Aged; Minerals; Oligospermia; Selenium; Semen; Sperm Motility; Spermatozoa; Teratozoospermia; Vitamins; Zinc
Божедомов В. А. Владимир Александрович 1961-
Липатова Н. А. Наталия Александровна 0001-
Божедомова Г. Е. Галина Евгеньевна 1967-
Рохликов И. М. Игорь Михайлович 1965-
Шчербакова Е. В.
Комарина Р. А.
Bozhedomov V. A. Vladimir Aleksandrovich 1961-
Lipatova N. A. Nataliya Aleksandrovna 0001-
Bozhedomova G. E. Galina Evgenyevna 1967-
Rokhlikov I. M. Igor` Mikhaylovich 1965-
Shcherbakova E. V.
Komarina R. A.
Using L- and acetyl-L-carnintines in combination with clomiphene citrate and antioxidant complex for treating idiopathic male infertility: a prospective randomized trial
Using L- and acetyl-L-carnintines in combination with clomiphene citrate and antioxidant complex for treating idiopathic male infertility: a...
Текст визуальный непосредственный
Урология
Бионика Медиа
Вып. 3 С. 22-32
2017
Статья
anti-estrogens anti-oxidants carnitine clomiphene citrate male infertility
acetylcarnitine antioxidant clomifene mineral selenium vitamin zinc adult Asthenozoospermia combination drug therapy controlled study drug effects human male middle aged oligospermia randomized controlled trial sperm spermatozoon spermatozoon motility Teratozoospermia Acetylcarnitine Adult Antioxidants Asthenozoospermia Clomiphene Drug Therapy, Combination Humans Male Middle Aged Minerals Oligospermia Selenium Semen Sperm Motility Spermatozoa Teratozoospermia Vitamins Zinc
The most common cause of male infertility is idiopathic oligo-, and or astheno-, and /or teratozoospermia. In such cases, anti-estrogens, antioxidants (vitamins and trace elements) or carnitines are used, but the evidence on their effectiveness is inconsistent; there are currently no published studies exploring their concurrent use.AIM: To investigate the efficacy and safety of the L- and acetyl-L-carnitine complex, vitamins A, E, C, selenium, zinc and other antioxidants ("SpermActin" + "More than vitamins") in combination with clomiphene citrate (CC) in managing male idiopathic infertility in the form of oligo, and/or astheno-, and/or teratozoospermia.MATERIALS AND METHODS: The study comprised 173 men from infertile couples aged 25-45 years who were divided into two groups - the study group (n=88) and control group (n=85). All the patients were examined according to the WHO recommendations. Patients of the study group received L-carnitine fumarate (1 g), acetyl-L-carnitine (0.5 g) twi