A chronobiological approach to therapy for depression

In the modern world, the discrepancy between biological and social rhythms in the presence of the existing genetic predisposition increases a risk for the occurrence and chronicity of depression. To solve this problem, various approaches, including a chronobiological one, are applied. Objective: to explore the relationship between chronobiological characteristics and psychopharmacotherapy in patients with depression. Patients and methods Eighty patients with depression, among whom women (68.7[%]) predominated, were examined. The age of the patients was 18-75 years (47.6±15.6 years). Their chronotype was identified using the Morningness-Eveningness Questionnaire (MEQ) to determine the type of circadian rhythm. Changes in the patients' status were clinically assessed utilizing the psychometric indicators. Results. Sleep disorders were most pronounced in recurrent depression (4.1±1.1 scores) (Montgomery-Asberg Depression Rating Scale, MADRS, item 4). The inverted pattern of daily variations