Pharmaceutical Chemistry Journal
Vol.51, Issue8, P. 695-697
Аннотация:
Medicinal effects on gastrointestinal-tract (GIT) organs under normal and pathological conditions are reviewed and analyzed. It is shown that rhythmic processes of digestive organs interact closely with the hierarchical structure of partial in vivo rhythms. This creates the prerequisites for prescribing medicines for GIT disorders considering individual in vivo chronorhythms and drug pharmacokinetic profiles. © 2017, Springer Science+Business Media, LLC, part of Springer Nature.
Ключевые слова:
chronopathology; chronorhythm; circadian rhythms; desynchronosis; digestive system
antacid agent; astringent agent; cholinergic receptor blocking agent; digestive tract agent; histamine H2 receptor antagonist; proton pump inhibitor; Article; chronobiology; chronopharmacology; chronotherapy; circadian rhythm; desynchronosis; drug dose regimen; drug efficacy; eradication therapy; gastrointestinal tract; human; intestine absorption; sleep disorder; therapy effect; treatment outcome
Bunyatyan N. D. Natal`ya Dmitrievna 1955-
Drogovoz S. M.
Kononenko A. V.
Olefir Yu. V. Yurij Vitalyevich 1961-
Prokofyev A. B. Aleksej Borisovich 1964-
Бунятян Н. Д. Наталья Дмитриевна 1955-
Дроговоз С. М.
Кононенко А. В.
Олефир Ю. В. Юрий Витальевич 1961-
Прокофьев А. Б. Алексей Борисович 1964-
Optimization of Drug Administration Dosage Regimen Considering Chronorhythms and Desynchronosis of Gastrointestinal-Tract Organs
Текст визуальный непосредственный
Pharmaceutical Chemistry Journal
Springer New York Consultants Bureau
Vol.51, Issue8 P. 695-697
2017
Статья
chronopathology chronorhythm circadian rhythms desynchronosis digestive system
antacid agent astringent agent cholinergic receptor blocking agent digestive tract agent histamine H2 receptor antagonist proton pump inhibitor Article chronobiology chronopharmacology chronotherapy circadian rhythm desynchronosis drug dose regimen drug efficacy eradication therapy gastrointestinal tract human intestine absorption sleep disorder therapy effect treatment outcome
Medicinal effects on gastrointestinal-tract (GIT) organs under normal and pathological conditions are reviewed and analyzed. It is shown that rhythmic processes of digestive organs interact closely with the hierarchical structure of partial in vivo rhythms. This creates the prerequisites for prescribing medicines for GIT disorders considering individual in vivo chronorhythms and drug pharmacokinetic profiles. © 2017, Springer Science+Business Media, LLC, part of Springer Nature.