Antioxidant Properties of Herbal Mixtures Improving Cognitive-Mnestic Functions
Shilova I. V., Suslov N. I., Korotkova E. I., Samy'lina I. A., Petrova E. V., Mazin E. V., Kovaleva T. Yu., Minakova M. Y.
Pharmaceutical Chemistry Journal
Vol.51, Issue8, P. 678-682
Опубликовано: 2017
Тип ресурса: Статья
DOI:10.1007/s11094-017-1673-5
Аннотация:
Decoctions of herbal mixtures I (including 30[%] Filipendula ulmaria meadowsweet grass, 10[%] bilberry shoots, and 60[%] Bergenia crassifolia green leaves) and II (60[%] meadowsweet grass, 10[%] bilberry shoots, and 30[%] bergenia green leaves) exhibited antioxidant activity. Biologically active substances of herbal mixture I exhibited predominantly catalytic decomposition of hydrogen peroxide formed during electroreduction of oxygen. Active substances of herbal mixture II interacted with oxygen radicals generated as a result of oxygen electroreduction on the electrode surface (EC mechanism) and were more effective than both dihydroquercetin and ascorbic acid. Herbal mixtures I and II normalized the content of thiobarbiturate-reactive products in brain homogenates under conditions of hypoxia-activated lipid peroxidation. In addition, herbal mixture II reduced the concentration of antiradical antioxidants in the lipid extracts. The antioxidant properties were inherent to a greater extent in mixture
Ключевые слова:
bergenia; bilberry; brain; cathodic voltammetry; flavonoids; hypoxia; lipid peroxidation; meadowsweet
4 hydroxycoumarin derivative; amino acid; antioxidant; ascorbic acid; carboxylic acid; flavonoid; free radical; herbaceous agent; herbal mixtures I; herbal mixtures II; hydrogen peroxide; lipid; oxygen radical; phenol derivative; phenolcarboxylic acid; tannin; taxifolin; trace element; unclassified drug; animal experiment; antioxidant activity; Article; Bergenia crassifolia; bilberry; brain homogenate; brain hypoxia; cognition; drug synthesis; electrochemistry; Filipendula; Filipendula ulmaria; Filipendula ulmaria meadowsweet grass; grass; lipid peroxidation; macronutrient; male; meadowsweet grass; medicinal plant; mouse; nonhuman; plant leaf; shoot; spectrophotometry
Язык текста: Английский
ISSN: 1573-9031
Shilova I. V.
Suslov N. I.
Korotkova E. I.
Samy'lina I. A. Irina Aleksandrovna 1943-
Petrova E. V.
Mazin E. V.
Kovaleva T. Yu. Tat`yana Yuryevna 1975-
Minakova M. Y.
Шилова И. В.
Суслов Н. И.
Короткова Е. И.
Самылина И. А. Ирина Александровна 1943-
Петрова Е. В.
Мазин Е. В.
Ковалева Т. Ю. Татьяна Юрьевна 1975-
Минакова М. Y.
Antioxidant Properties of Herbal Mixtures Improving Cognitive-Mnestic Functions
Текст визуальный непосредственный
Pharmaceutical Chemistry Journal
Springer New York Consultants Bureau
Vol.51, Issue8 P. 678-682
2017
Статья
bergenia bilberry brain cathodic voltammetry flavonoids hypoxia lipid peroxidation meadowsweet
4 hydroxycoumarin derivative amino acid antioxidant ascorbic acid carboxylic acid flavonoid free radical herbaceous agent herbal mixtures I herbal mixtures II hydrogen peroxide lipid oxygen radical phenol derivative phenolcarboxylic acid tannin taxifolin trace element unclassified drug animal experiment antioxidant activity Article Bergenia crassifolia bilberry brain homogenate brain hypoxia cognition drug synthesis electrochemistry Filipendula Filipendula ulmaria Filipendula ulmaria meadowsweet grass grass lipid peroxidation macronutrient male meadowsweet grass medicinal plant mouse nonhuman plant leaf shoot spectrophotometry
Decoctions of herbal mixtures I (including 30[%] Filipendula ulmaria meadowsweet grass, 10[%] bilberry shoots, and 60[%] Bergenia crassifolia green leaves) and II (60[%] meadowsweet grass, 10[%] bilberry shoots, and 30[%] bergenia green leaves) exhibited antioxidant activity. Biologically active substances of herbal mixture I exhibited predominantly catalytic decomposition of hydrogen peroxide formed during electroreduction of oxygen. Active substances of herbal mixture II interacted with oxygen radicals generated as a result of oxygen electroreduction on the electrode surface (EC mechanism) and were more effective than both dihydroquercetin and ascorbic acid. Herbal mixtures I and II normalized the content of thiobarbiturate-reactive products in brain homogenates under conditions of hypoxia-activated lipid peroxidation. In addition, herbal mixture II reduced the concentration of antiradical antioxidants in the lipid extracts. The antioxidant properties were inherent to a greater extent in mixture