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Botulinum toxin treatment of lower extremity spasticity

Хат'кова С. Е., Акулов М. А., Орлова О. Р., Усачев Д. Y., Орлова А. С., Крyлова Л. В.
Нервно-мышечные болезни
Т. 7, Вып. 3, С. 21-35
Опубликовано: 2017
Тип ресурса: Статья

DOI:10.17650/2222-8721-2017-7-3-21-35

Аннотация:
The article reviews the current concept of lower extremity spasticity, which is a frequent disabling consequence of stroke. Gait biomechanics, step cycle and main pathologic patterns of lower extremity are described (hip adduction, knee flexion, knee extension, foot plantar flexion, equinovarus foot position, toes flexion, hallux extension), including muscles involved in the pathological process. Additionally the article contains detailed information on pathologic principles of lower extremity spasticity development. Special focus is given to sarcomeregenesis as an essential element of the development of potential conditions for muscle tissue adaptation to a new state and restoration of muscle length and strength. At present Botulinum toxin A (BTA) is used in a complex spasticity management programs. The results of clinical studies performed in the last decade supporting the efficacy of Botox® (Onabotulinumtoxin A) in the treatment of spasticity are reviewed. Effective BTA doses are pr
Ключевые слова:
Botulinum toxin; Gait; Lower extremity; Spasticity; Spasticity pattern; Stroke
Язык текста: Русский
ISSN: 2413-0443
Хат'кова С. Е.
Акулов М. А.
Орлова О. Р. Ольга Ратмировна 1958-
Усачев Д. Y.
Орлова А. С. Александра Сергеевна 1986-
Крyлова Л. В.
Khat'kova S. E.
Akulov M. A.
Orlova O. R. Ol`ga Ratmirovna 1958-
Usachev D. Y.
Orlova A. S. Aleksandra Sergeevna 1986-
Krylova L. V.
Botulinum toxin treatment of lower extremity spasticity
Текст визуальный непосредственный
Нервно-мышечные болезни
Издательский дом "АБВ-пресс"
Т. 7, Вып. 3 С. 21-35
2017
Статья
Botulinum toxin Gait Lower extremity Spasticity Spasticity pattern Stroke
The article reviews the current concept of lower extremity spasticity, which is a frequent disabling consequence of stroke. Gait biomechanics, step cycle and main pathologic patterns of lower extremity are described (hip adduction, knee flexion, knee extension, foot plantar flexion, equinovarus foot position, toes flexion, hallux extension), including muscles involved in the pathological process. Additionally the article contains detailed information on pathologic principles of lower extremity spasticity development. Special focus is given to sarcomeregenesis as an essential element of the development of potential conditions for muscle tissue adaptation to a new state and restoration of muscle length and strength. At present Botulinum toxin A (BTA) is used in a complex spasticity management programs. The results of clinical studies performed in the last decade supporting the efficacy of Botox® (Onabotulinumtoxin A) in the treatment of spasticity are reviewed. Effective BTA doses are pr