Study of the influence of cholesterol on pharmaceutical parameters and antitumor activity of liposomal analogue hypothalamic hormone somatostatin
Санарова Е. В., Ланцова А. В., Дмитриева М. В., Жанг Х., Киселева М. П., Борисова Л. М., Орлова О. Л., Полозкова А. П., Краснук И. И., Оборотова Н. А.
Биофармацевтический журнал
Т. 9, Вып. 5, С. 22-26
Опубликовано: 2017
Тип ресурса: Статья
Аннотация:
Despite considerable breakthrough in the chemotherapy of tumors remains a topical search of new active pharmaceutical substances having desirable properties such as high antitumor activity, selective effect on tumor cells and decreased side effects. One of these substances is a new domestic analogue of hypothalamic hormone somatostatin (AHHS), synthesized in the N. N. Blokhin RCRC. This substance during preliminary biological experiments showed a high antitumor activity, but further to create a dosage form having difficulty due AHHS insolubility in water. As an alternative way to overcome the hydrophobic nature of the substances the use of liposomes suggested AHHS providing intravenous administration of the drug and a positive effect on its pharmacokinetics. In the present study we were obtained and characterized by liposomes AHHS adding egg lecithin and cholesterol without it. In vivo experiments assessed the two models the antitumor activity of liposomal formulation AHHS on breast ad
Ключевые слова:
Antitumor activity; Cholesterol; Inhibition of tumor growth; Liposomes; Somatostatin analogue
biological product; calcium; cholesterol; hypothalamus hormone; liposome; phosphatidylcholine; somatostatin; somatostatin derivative; antineoplastic activity; Article; breast adenocarcinoma; cancer model; hydrophobicity; pharmacological parameters; solubility; tumor growth
Язык текста: Русский
ISSN: 2073-8099
Санарова Е. В.
Ланцова А. В.
Дмитриева М. В. Мария Вячеславовна 0001-
Жанг Х.
Киселева М. П.
Борисова Л. М.
Орлова О. Л.
Полозкова А. П.
Краснук И. И.
Оборотова Н. А. Наталия Александровна 1949-
Sanarova E. V.
Lantsova A. V.
Dmitrieva M. V. Mariya Vyacheslavovna 0001-
Zhang X.
Kiseleva M. P.
Borisova L. M.
Orlova O. L.
Polozkova A. P.
Krasnuk I. I.
Oborotova N. A. Nataliya Aleksandrovna 1949-
Study of the influence of cholesterol on pharmaceutical parameters and antitumor activity of liposomal analogue hypothalamic hormone somatostatin
Текст визуальный непосредственный
Биофармацевтический журнал
ООО "Фолиум"
Т. 9, Вып. 5 С. 22-26
2017
Статья
Antitumor activity Cholesterol Inhibition of tumor growth Liposomes Somatostatin analogue
biological product calcium cholesterol hypothalamus hormone liposome phosphatidylcholine somatostatin somatostatin derivative antineoplastic activity Article breast adenocarcinoma cancer model hydrophobicity pharmacological parameters solubility tumor growth
Despite considerable breakthrough in the chemotherapy of tumors remains a topical search of new active pharmaceutical substances having desirable properties such as high antitumor activity, selective effect on tumor cells and decreased side effects. One of these substances is a new domestic analogue of hypothalamic hormone somatostatin (AHHS), synthesized in the N. N. Blokhin RCRC. This substance during preliminary biological experiments showed a high antitumor activity, but further to create a dosage form having difficulty due AHHS insolubility in water. As an alternative way to overcome the hydrophobic nature of the substances the use of liposomes suggested AHHS providing intravenous administration of the drug and a positive effect on its pharmacokinetics. In the present study we were obtained and characterized by liposomes AHHS adding egg lecithin and cholesterol without it. In vivo experiments assessed the two models the antitumor activity of liposomal formulation AHHS on breast ad