Obesity, metabolic syndrome, and thrombophilia

Objective. To comprehensively analyze the data available in the current literature on a pathogenetic relationship between obesity and thrombophilia in the development of obstetric and thrombotic events in female patients with metabolic syndrome (MS). Material and methods. The review included the data of foreign and Russian articles published in the past 10 years and found in PubMed and e-Library on this topic. Results. The paper clearly shows possible mechanisms and a pathogenetic relationship between endocrine, proinflammatory, and prothrombotic statuses observed in patients with MS in the development of obstetric and thrombotic events. Conclusion. Despite a significant number of investigations of the risk factors and pathogenetic mechanisms for the development of thromboembolic events in MS patients, the problem of identifying the causes and ways of correcting the abnormalities has not been fully resolved and requires further study. Moreover, the annually increasing percent of person