Аннотация:
Aim: To investigate the impact of menopausal hormone therapy (MHT) on the expression of risk factors for cardiovascular events (CVEs) in patients with Shereshevsky-Turner syndrome (STS); to elaborate an algorithm for patient management using MHT. Subjects and methods: From 2010 to 2012, a total of 41 patients aged 14 to 35 years with STS were examined in the framework of a prospective observational study. 100 STS case histories in 2000 to 2009 were retrospectively analyzed. The indicators of the so-called cardiometabolic risk, such as body mass index (BMI), lipidogram readings, venous plasma glucose levels, and blood pressure, were estimated in relation to the type of MHT. In the prospective part of the investigation, an angioscan was used to estimate vessel characteristics (stiffness, wall tone, endothelial function (EF)), by using the examination data. Results: 90[%] of the patients with STS were found to have risk factors for CVEs: atherogenic dyslipidemia (85[%]; 51[%] in the general fem
Ключевые слова:
Cardiovascular events; Estrogens; M enopausal hormone therapy; Risk factors; Shereshevsky-Turner syndrome
estradiol; estrogen; high density lipoprotein cholesterol; adult; algorithm; arterial stiffness; atherosclerosis; blood; blood pressure measurement; cardiovascular disease; dose response; drug effects; estrogen therapy; female; human; medication therapy management; metabolism; procedures; Russian Federation; statistics and numerical data; treatment outcome; Turner syndrome; vascular endothelium; Adult; Algorithms; Atherosclerosis; Blood Pressure Determination; Cardiovascular Diseases; Cholesterol, HDL; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; Estrogen Replacement Therapy; Estrogens; Female; Humans; Medication Therapy Management; Outcome and Process Assessment (Health Care); Russia; Turner Syndrome; Vascular Stiffness
Ьевстигнеева О. А.
Андреева Е. Н.
Григорян О. Р. Ольга Рафаэльевна 1971-
Волеводз Н. Н. Наталья Никитична 1962-
Мельниченко Г. А. Галина Афанасьевна 1946-
Дедов И. И. Иван Иванович 1941-
Yevstigneeva O. A.
Andreeva E. N.
Grigoryan O. R. Ol`ga Rafae`lyevna 1971-
Volevodz N. N. Natal`ya Nikitichna 1962-
Mel`nichenko G. A. Galina Afanasyevna 1946-
Dedov I. I. Ivan Ivanovich 1941-
Shereshevsky-Turner syndrome: Estrogen replacement therapy and cardiovascular risk factors
Текст визуальный непосредственный
Терапевтический архив
Медицинское маркетинговое агентство "МедиаМедика"
Т. 89, Вып. 10 С. 48-53
2017
Статья
Cardiovascular events Estrogens M enopausal hormone therapy Risk factors Shereshevsky-Turner syndrome
estradiol estrogen high density lipoprotein cholesterol adult algorithm arterial stiffness atherosclerosis blood blood pressure measurement cardiovascular disease dose response drug effects estrogen therapy female human medication therapy management metabolism procedures Russian Federation statistics and numerical data treatment outcome Turner syndrome vascular endothelium Adult Algorithms Atherosclerosis Blood Pressure Determination Cardiovascular Diseases Cholesterol, HDL Dose-Response Relationship, Drug Endothelium, Vascular Estradiol Estrogen Replacement Therapy Estrogens Female Humans Medication Therapy Management Outcome and Process Assessment (Health Care) Russia Turner Syndrome Vascular Stiffness
Aim: To investigate the impact of menopausal hormone therapy (MHT) on the expression of risk factors for cardiovascular events (CVEs) in patients with Shereshevsky-Turner syndrome (STS); to elaborate an algorithm for patient management using MHT. Subjects and methods: From 2010 to 2012, a total of 41 patients aged 14 to 35 years with STS were examined in the framework of a prospective observational study. 100 STS case histories in 2000 to 2009 were retrospectively analyzed. The indicators of the so-called cardiometabolic risk, such as body mass index (BMI), lipidogram readings, venous plasma glucose levels, and blood pressure, were estimated in relation to the type of MHT. In the prospective part of the investigation, an angioscan was used to estimate vessel characteristics (stiffness, wall tone, endothelial function (EF)), by using the examination data. Results: 90[%] of the patients with STS were found to have risk factors for CVEs: atherogenic dyslipidemia (85[%]; 51[%] in the general fem